Patients undergoing mania and mixed episodes carrying the COMT allele G had better performance on executive function, memory, verbal fluency, and intelligence tests.
We observed a significant association between homozygosis for the rs4680COMT low-activity variant and a reduced recurrence of manic, but not depressive, episodes during the course of the illness.
Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder.