| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | AlteredExpression | group | BEFREE | Prolonged autoimmune injures in the retinal territory will triggers and maintains a low-grade chronic inflammation process, microvascular alterations, glial proliferation and subsequent fibrosis and worse, progressive apoptosis of the photoreceptor neurons.Patients with long-standing DM disturbances in retinal BRBs suffer of alterations in the enzymatic pathways of polyunsaturated fatty acids (PUFAs), increase release of free radicals and pro-inflammatory molecules and subsequently incremented levels of vascular endothelial growth factor. | 31092270 | 2019 | ||||
|
0.370 | Biomarker | group | CTD_human | Gene expression profiling of changes induced by maternal diabetes in the embryonic heart. | 26073000 | 2015 | ||||
|
0.370 | Biomarker | group | BEFREE | Shared nodes across all networks reflected established pathogenic mechanisms of diabetes complications, such as elements of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) and vascular endothelial growth factor receptor (VEGFR) signaling pathways. | 23139354 | 2013 | ||||
|
0.370 | GeneticVariation | group | BEFREE | Our results could help elucidate the role of VEGF splice variants in diabetic complications. | 17961532 | 2008 | ||||
|
0.370 | GeneticVariation | group | BEFREE | The VEGF +405 genotype was not associated with diabetic complications in type 2 diabetes patients. | 17121786 | 2007 | ||||
|
0.370 | Biomarker | group | BEFREE | Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor and is implicated in both of these diabetes complications. | 14988276 | 2004 | ||||
|
0.370 | Biomarker | group | BEFREE | Thus, VEGF therapy may be useful in the treatment of diabetic complications characterized by impaired neovascularization. | 15161630 | 2004 | ||||
|
0.370 | Biomarker | group | BEFREE | Recent studies suggest that increased expression of the cytokine vascular endothelial growth factor (VEGF) may play a role in the pathogenesis of diabetic complications. | 12505748 | 2003 |