Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 79447
Gene Symbol: PAGR1
PAGR1
0.050 Biomarker phenotype BEFREE Streptococcus pyogenes (group A streptococcus; GAS) is an important gram-positive human pathogen capable of causing diseases ranging from mild superficial skin and pharyngeal infections to more severe invasive diseases, including streptococcal toxic shock syndrome (STSS). 31735631 2020
Entrez Id: 2588
Gene Symbol: GALNS
GALNS
0.050 Biomarker phenotype BEFREE Streptococcus pyogenes (group A streptococcus; GAS) is an important gram-positive human pathogen capable of causing diseases ranging from mild superficial skin and pharyngeal infections to more severe invasive diseases, including streptococcal toxic shock syndrome (STSS). 31735631 2020
Entrez Id: 2520
Gene Symbol: GAST
GAST
0.050 Biomarker phenotype BEFREE Streptococcus pyogenes (group A streptococcus; GAS) is an important gram-positive human pathogen capable of causing diseases ranging from mild superficial skin and pharyngeal infections to more severe invasive diseases, including streptococcal toxic shock syndrome (STSS). 31735631 2020
Entrez Id: 79447
Gene Symbol: PAGR1
PAGR1
0.050 Biomarker phenotype BEFREE We report the case of an adult woman with lactational amenorrhea and GAS vulvovaginitis progressing to STSS. 31151810 2019
Entrez Id: 2520
Gene Symbol: GAST
GAST
0.050 Biomarker phenotype BEFREE We report the case of an adult woman with lactational amenorrhea and GAS vulvovaginitis progressing to STSS. 31151810 2019
Entrez Id: 2588
Gene Symbol: GALNS
GALNS
0.050 Biomarker phenotype BEFREE We report the case of an adult woman with lactational amenorrhea and GAS vulvovaginitis progressing to STSS. 31151810 2019
Entrez Id: 2520
Gene Symbol: GAST
GAST
0.050 Biomarker phenotype BEFREE Streptococcus pyogenes (group A Streptococcus; GAS) causes clinical diseases, including pharyngitis, scarlet fever, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. 28355251 2017
Entrez Id: 2588
Gene Symbol: GALNS
GALNS
0.050 Biomarker phenotype BEFREE Streptococcus pyogenes (group A Streptococcus; GAS) causes clinical diseases, including pharyngitis, scarlet fever, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. 28355251 2017
Entrez Id: 79447
Gene Symbol: PAGR1
PAGR1
0.050 Biomarker phenotype BEFREE Streptococcus pyogenes (group A Streptococcus; GAS) causes clinical diseases, including pharyngitis, scarlet fever, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. 28355251 2017
Entrez Id: 2520
Gene Symbol: GAST
GAST
0.050 Biomarker phenotype BEFREE Streptococcus pyogenes (group A Streptococcus; GAS) is a widespread human pathogen and causes streptococcal toxic shock syndrome (STSS). 27349341 2016
Entrez Id: 79447
Gene Symbol: PAGR1
PAGR1
0.050 Biomarker phenotype BEFREE Streptococcus pyogenes (group A Streptococcus; GAS) is a widespread human pathogen and causes streptococcal toxic shock syndrome (STSS). 27349341 2016
Entrez Id: 2588
Gene Symbol: GALNS
GALNS
0.050 Biomarker phenotype BEFREE Streptococcus pyogenes (group A Streptococcus; GAS) is a widespread human pathogen and causes streptococcal toxic shock syndrome (STSS). 27349341 2016
Entrez Id: 79447
Gene Symbol: PAGR1
PAGR1
0.050 Biomarker phenotype BEFREE Among the 1542 invasive GAS strains studied, 78% (n=1206) were from blood cultures, and a streptococcal toxic shock syndrome (STSS) was described in 22% (n=340) of cases, mainly associated with necrotizing fasciitis (NF) and pleuro-pulmonary infections (p<0.001).The in-hospital fatality rate was 15%. 21883669 2012
Entrez Id: 2520
Gene Symbol: GAST
GAST
0.050 Biomarker phenotype BEFREE Among the 1542 invasive GAS strains studied, 78% (n=1206) were from blood cultures, and a streptococcal toxic shock syndrome (STSS) was described in 22% (n=340) of cases, mainly associated with necrotizing fasciitis (NF) and pleuro-pulmonary infections (p<0.001).The in-hospital fatality rate was 15%. 21883669 2012
Entrez Id: 2588
Gene Symbol: GALNS
GALNS
0.050 Biomarker phenotype BEFREE Among the 1542 invasive GAS strains studied, 78% (n=1206) were from blood cultures, and a streptococcal toxic shock syndrome (STSS) was described in 22% (n=340) of cases, mainly associated with necrotizing fasciitis (NF) and pleuro-pulmonary infections (p<0.001).The in-hospital fatality rate was 15%. 21883669 2012
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.020 GeneticVariation phenotype BEFREE Here, we phenotypically characterized FoxP3/GARP/LAP-expressing Tregs in GAS-infected or SAg (SmeZ)-stimulated splenocytes from transgenic (tg) mice expressing human HLA-II DRB1*15 (DR15 allele associated with nonsevere NF/STSS-protective responses) or DRB1*0402/DQB1*0302 (DR4/DQ8 alleles associated with neutral risk for combined NF/STSS). 30224551 2018
Entrez Id: 129831
Gene Symbol: RBM45
RBM45
0.020 GeneticVariation phenotype BEFREE Here, we phenotypically characterized FoxP3/GARP/LAP-expressing Tregs in GAS-infected or SAg (SmeZ)-stimulated splenocytes from transgenic (tg) mice expressing human HLA-II DRB1*15 (DR15 allele associated with nonsevere NF/STSS-protective responses) or DRB1*0402/DQB1*0302 (DR4/DQ8 alleles associated with neutral risk for combined NF/STSS). 30224551 2018
Entrez Id: 3778
Gene Symbol: KCNMA1
KCNMA1
0.020 Biomarker phenotype BEFREE Most isolates had scpA, ska, saga, and slo genes, whereas speC, speG, speH, speI, speK, smez, and ssa genes were not detected. speA gene was identified only in one patient with STSS (1/6, 17%). 24210866 2014
Entrez Id: 3778
Gene Symbol: KCNMA1
KCNMA1
0.020 AlteredExpression phenotype BEFREE The rgg mutants from STSS clinical isolates enhanced lethality and impaired various organs in the mouse models, similar to the csrS mutants, and precluded their being killed by human neutrophils, mainly due to an overproduction of SLO. 20368967 2010
Entrez Id: 129831
Gene Symbol: RBM45
RBM45
0.020 GeneticVariation phenotype BEFREE Our epidemiologic studies on invasive Group A Streptococci (GAS) infections identified specific HLA class II haplotypes/alleles conferring high-risk or protection from streptococcal toxic shock syndrome with a strong protection conferred by the DRB1*15/DQB1*06 haplotype. 17312154 2007
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.020 GeneticVariation phenotype BEFREE Our epidemiologic studies on invasive Group A Streptococci (GAS) infections identified specific HLA class II haplotypes/alleles conferring high-risk or protection from streptococcal toxic shock syndrome with a strong protection conferred by the DRB1*15/DQB1*06 haplotype. 17312154 2007
Entrez Id: 7939
Gene Symbol: LAP
LAP
0.010 AlteredExpression phenotype BEFREE Here, we phenotypically characterized FoxP3/GARP/LAP-expressing Tregs in GAS-infected or SAg (SmeZ)-stimulated splenocytes from transgenic (tg) mice expressing human HLA-II DRB1*15 (DR15 allele associated with nonsevere NF/STSS-protective responses) or DRB1*0402/DQB1*0302 (DR4/DQ8 alleles associated with neutral risk for combined NF/STSS). 30224551 2018
Entrez Id: 2615
Gene Symbol: LRRC32
LRRC32
0.010 Biomarker phenotype BEFREE Here, we phenotypically characterized FoxP3/GARP/LAP-expressing Tregs in GAS-infected or SAg (SmeZ)-stimulated splenocytes from transgenic (tg) mice expressing human HLA-II DRB1*15 (DR15 allele associated with nonsevere NF/STSS-protective responses) or DRB1*0402/DQB1*0302 (DR4/DQ8 alleles associated with neutral risk for combined NF/STSS). 30224551 2018
Entrez Id: 811
Gene Symbol: CALR
CALR
0.010 GeneticVariation phenotype BEFREE Most isolates had scpA, ska, saga, and slo genes, whereas speC, speG, speH, speI, speK, smez, and ssa genes were not detected. speA gene was identified only in one patient with STSS (1/6, 17%). 24210866 2014
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.010 GeneticVariation phenotype BEFREE Most isolates had scpA, ska, saga, and slo genes, whereas speC, speG, speH, speI, speK, smez, and ssa genes were not detected. speA gene was identified only in one patient with STSS (1/6, 17%). 24210866 2014