Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.070 | GeneticVariation | disease | BEFREE | Here, we investigated whether IL-6 -174 G>C, IL-8 +396 G>T, and TGF-β1 +869 G>C and +915 G>C polymorphisms were associated with susceptibility to HPV infection in women from north-east (Pernambuco) Brazil. | 27783717 | 2016 | ||||
|
0.070 | Biomarker | disease | BEFREE | In a multivariate analysis, IL-6 secretion and the percentage of CD71-positive T lymphocytes both uniquely predicted survival independent of HPV infection status. | 26079381 | 2015 | ||||
|
0.070 | Biomarker | disease | BEFREE | Although it is reported that interleukin (IL)-6/signal transducer and activator of transcription 3 (STAT3) is activated by human papillomavirus (HPV) infection in cervical cancer cells, little is known about the role of IL-6/STAT3 in tumour microenvironment during development of the disease. | 23953057 | 2013 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | The study suggests that HPV infection-induced IL-17 levels can stimulate Mcl-1 expression through the PI3K pathway and promote lung tumor cell progression through a p53- and IL-6-independent pathway. | 20578176 | 2010 | ||||
|
0.070 | Biomarker | disease | BEFREE | Although cervical HPV infection increased the concentrations of both IL-6 and IL-1 beta but HPV induced abnormal cervical smear was associated only with increased IL-6 concentrations significantly. | 19010320 | 2009 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | The IL10 GCC haplotype has been associated with production of relatively high levels of interleukin (IL)-10, which could (a) inhibit cytokines such as IL-2, TNF-alpha, IL-4, IL-6, and IL-12 that are involved in the T(H)1-T(H)2 immunoregulation; (b) down-regulate expression of MHC class I and class II molecules; or (c) induce the transcription of early promoter of HPV, all potentially contributing to duration of HPV infection among immunosuppressed individuals. | 17684137 | 2007 | ||||
|
0.070 | Biomarker | disease | BEFREE | During genital human papillomavirus (HPV) infection several cytokines are released, such as interleukin-1 (IL-1), tumor necrosis factoralpha (TNFalpha), IL-6, and IL-8. | 10820487 | 2000 |