Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.070 GeneticVariation disease BEFREE Here, we investigated whether IL-6 -174 G>C, IL-8 +396 G>T, and TGF-β1 +869 G>C and +915 G>C polymorphisms were associated with susceptibility to HPV infection in women from north-east (Pernambuco) Brazil. 27783717 2016
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.070 Biomarker disease BEFREE In a multivariate analysis, IL-6 secretion and the percentage of CD71-positive T lymphocytes both uniquely predicted survival independent of HPV infection status. 26079381 2015
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.070 Biomarker disease BEFREE Although it is reported that interleukin (IL)-6/signal transducer and activator of transcription 3 (STAT3) is activated by human papillomavirus (HPV) infection in cervical cancer cells, little is known about the role of IL-6/STAT3 in tumour microenvironment during development of the disease. 23953057 2013
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.070 AlteredExpression disease BEFREE The study suggests that HPV infection-induced IL-17 levels can stimulate Mcl-1 expression through the PI3K pathway and promote lung tumor cell progression through a p53- and IL-6-independent pathway. 20578176 2010
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.070 Biomarker disease BEFREE Although cervical HPV infection increased the concentrations of both IL-6 and IL-1 beta but HPV induced abnormal cervical smear was associated only with increased IL-6 concentrations significantly. 19010320 2009
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.070 AlteredExpression disease BEFREE The IL10 GCC haplotype has been associated with production of relatively high levels of interleukin (IL)-10, which could (a) inhibit cytokines such as IL-2, TNF-alpha, IL-4, IL-6, and IL-12 that are involved in the T(H)1-T(H)2 immunoregulation; (b) down-regulate expression of MHC class I and class II molecules; or (c) induce the transcription of early promoter of HPV, all potentially contributing to duration of HPV infection among immunosuppressed individuals. 17684137 2007
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.070 Biomarker disease BEFREE During genital human papillomavirus (HPV) infection several cytokines are released, such as interleukin-1 (IL-1), tumor necrosis factoralpha (TNFalpha), IL-6, and IL-8. 10820487 2000