Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 Biomarker disease BEFREE The present study was designed to investigate the association between a change in vaginal local immunity and human papilloma virus (HPV) infection outcome in patients with cervical lesions, through the study of the expression of vaginal local immune factors, interleukin (IL)-2, IL-10, secretory immunoglobulin A (sIgA) and IgG, in patients with different grades of cervical lesions and different degrees of cervical lesions caused by HPV infection prior to and following treatment. 31612062 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 GeneticVariation disease BEFREE The present work aimed to investigate the possible association between IL10 and TNFα promoter polymorphisms and HPV infection in the cervical carcinogenesis risk in women from Brazil. 29935877 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 AlteredExpression disease BEFREE The reduction of dominant Lactobacillus in the vagina, impairment of H<sub>2</sub>O<sub>2</sub> function, flora ratio imbalance, pathogen infections, reduction in IL-2/IL-10 ratio, and changes in SIgA and IgG levels could all be potential factors that influenced the pathogenicity of HPV infection and the occurrence and development of cervical lesions. 31405377 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 Biomarker disease BEFREE Therefore, combined detection of IL-10, Ki-67 and HPV infection can improve the diagnosis of CIN and early cervical cancer. 30546456 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 Biomarker disease BEFREE Therefore, this interplay between HPV and IL-10 creates a vicious cycle that could favor an immunosuppressive microenvironment in the cervix, facilitating the progression of a simple HPV infection to SIL or cervical cancer. 28365229 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 GeneticVariation disease BEFREE Therefore, we evaluated the influence of IL-10 c.-592C>A polymorphism in HPV infection and in IL-10 plasmatic/cervical levels in HPV infected and non-infected women. 28552689 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 GeneticVariation disease BEFREE The present study aims to find out the impact of IL-10 promoter polymorphisms at -1082A/G (rs1800896), -819C/T (rs1800872), and -592C/A (rs1800871) sites along with IL-10 production and HPV infection in the progression of cervical cancer. 25412954 2015
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 Biomarker disease BEFREE Interleukin-10 (IL-10) plays an important role in a host's defense against human papillomavirus (HPV) infection. 23430974 2013
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 GeneticVariation disease BEFREE Using High Resolution Melt analysis (HRM), we analyzed an SNP -1082A/G and -819C/T in interleukin-10 promoter region in 364 Brazilian women: 171 with cervical lesions and HPV infection, and 193 with normal cytological results and HPV-negative. 23800422 2013
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 Biomarker disease BEFREE Using longitudinal predictive indicators (SE, SP, PPV, NPV), IL-10 expression was of no value in predicting (1) the outcomes of HR-HPV infections, or (2) the surrogate endpoints (incident CIN1+, CIN2+) of progressive disease. 19908064 2009
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 AlteredExpression disease BEFREE Correlation between IL-10 gene expression and HPV infection in cervical cancer: a mechanism for immune response escape. 18798072 2008
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 AlteredExpression disease BEFREE The IL10 GCC haplotype has been associated with production of relatively high levels of interleukin (IL)-10, which could (a) inhibit cytokines such as IL-2, TNF-alpha, IL-4, IL-6, and IL-12 that are involved in the T(H)1-T(H)2 immunoregulation; (b) down-regulate expression of MHC class I and class II molecules; or (c) induce the transcription of early promoter of HPV, all potentially contributing to duration of HPV infection among immunosuppressed individuals. 17684137 2007
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 GeneticVariation disease BEFREE The IL-10 -1082G polymorphism is associated with clearance of HPV infection. 16907941 2006
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 GeneticVariation disease BEFREE IL-10 promoter nt -1082A/G polymorphism and human papillomavirus infection in cytologic abnormalities of the uterine cervix. 15144570 2004
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 Biomarker disease BEFREE The up-regulated secretion of IL-10 may inhibit immune responses against HPV infection in early cervical lesions, whereas up-regulated TNF-alpha and uncoordinated cytokine secretion (elevated both Th1 and Th2 cytokines) may reflect impaired or invalid responses in advanced stage lesions. 15668895 2004