Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.560 | Biomarker | disease | CTD_human | Deficiency of glycine N-methyltransferase results in deterioration of cellular defense to stress in mouse liver. | 21137059 | 2010 | ||||
|
0.560 | Biomarker | disease | BEFREE | Based on the identification of GNMT as a 4 S polyaromatic hydrocarbon-binding protein, we used liver cancer cell lines that expressed GNMT either transiently or stably in cDNA transfections to analyze the role of GNMT in the benzo(a)pyrene (BaP) detoxification pathway. | 15150120 | 2004 | ||||
|
0.560 | Biomarker | disease | MGD | Therefore, GNMT is a tumor suppressor gene for liver cancer, and it is associated with gender disparity in liver cancer susceptibility. | 19035462 | 2009 | ||||
|
0.560 | Biomarker | disease | BEFREE | Using genotypic characterization of GNMT in hepatoma cell lines and in a Taiwanese population with a high incidence of liver cancer we have investigated the role of this gene in the progression of liver cancer. | 12566309 | 2003 | ||||
|
0.560 | AlteredExpression | disease | BEFREE | Reduced GNMT expression was also found in human HCC tissue and liver cancer cell lines. | 31086990 | 2019 | ||||
|
0.560 | AlteredExpression | disease | BEFREE | Down-regulation of GNMT gene expression may be involved in the pathogenesis of liver cancer. | 9495250 | 1998 | ||||
|
0.560 | AlteredExpression | disease | BEFREE | High rates of GNMT knockout mice developed HCC, while overexpression of GNMT prevented aflatoxin-induced carcinogenicity and inhibited liver cancer cell proliferation. | 27153064 | 2016 | ||||
|
0.560 | Biomarker | disease | BEFREE | Therefore, GNMT is a tumor suppressor gene for liver cancer, and it is associated with gender disparity in liver cancer susceptibility. | 19035462 | 2009 | ||||
|
0.560 | Biomarker | disease | MGD | Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver. | 17937387 | 2007 |