Surprisingly, we found that low ALDH2 expression levels associated with high XRCC1 expression levels are indicative for a poor overall survival, particularly in lung and liver cancer patients.
Trial sequential analysis (TSA), false-positive report probabilities (FPRP), and combined genotype analysis revealed that XRCC1Arg399Gln is mainly associated with susceptibility to liver cancer.
This meta-analysis suggests the participation of XRCC1Arg399Gln is a genetic susceptibility for hepatocellular cancer in Asians and breast cancer in Indians.
We aimed to establish whether XRCC1, XRCC3, and XPD are associated with liver cancer in Pakistan and to examine the interaction of hepatitis B virus (HBV) or hepatitis C virus (HCV) with repaired genes in the occurrence of liver cancer.