Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.370 AlteredExpression disease BEFREE Large-duct iCCA and pCCA more frequently had the loss of SMAD4 expression and MDM2 amplifications than small-duct iCCA, whereas the loss of BAP1 expression and IDH1 mutations were mostly restricted to small-duct iCCA. 30170977 2019
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.370 AlteredExpression disease BEFREE The loss of SMAD4 expression was more common in MDM2-amplified iCCAs than in those without MDM2 amplification. 29309301 2018
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.370 Biomarker disease BEFREE Immunohistochemistry was performed on 6 mucinous and 12 conventional iCCs with matched age, sex, and stage, which revealed positive immunoreactivity in MUC1 (83% versus 58%), MUC2 (33% versus 17%), MUC5AC (100% versus 42%), MUC6 (50% versus 0), CK7 (83% versus 83%), CK20 (0 versus 17%), CDX2 (17% versus 0), p53 (67% versus 67%), Smad4 (67% versus 58%), and EGFR (83% versus 42%) in mucinous and conventional iCCs, respectively. 29698701 2018
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.370 GeneticVariation disease BEFREE Compared to M class ICCs (92-147 somatic mutations; n = 5) with a relative deficit of CNAs, C class ICCs (54-84 mutations; n = 5) harbor recurrent focal CNAs including deletions involving CDKN2A, ROBO1, ROBO2, RUNX3, and SMAD4. 27009864 2016
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.370 GeneticVariation disease BEFREE The most frequent genetic aberrations (GAs) observed were tumor protein 53 (TP53; 27%), cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B; 27%), KRAS (22%), AT-rich interactive domain-containing protein 1A (ARID1A; 18%), and isocitrate dehydrogenase 1 (IDH1; 16%) in IHCCA; KRAS (42%), TP53 (40%), CDKN2A/B (17%), and SMAD4 (21%) in EHCCA; and TP53 (59%), CDKN2A/B (19%), ARID1A (13%), and ERBB2 (16%) in GBCA. 27622582 2016
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.370 AlteredExpression disease BEFREE The expression of Smad4 was associated with the histological grade, clinical stage, and metastasis of ICC (P < 0.05). 23981608 2013
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.370 Biomarker disease CTD_human Exome sequencing of liver fluke-associated cholangiocarcinoma. 22561520 2012
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.370 AlteredExpression disease BEFREE Loss expression of DPC4/Smad4 gene was found both in stone-containing IHD and ICC. 16917866 2006