Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Here, we demonstrate that the inactivation of both Tp53 and Pten in the mouse mesothelium is sufficient to rapidly drive aggressive MMs. 29904909 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways. 28464864 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease CTD_human Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations. 26928227 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Furthermore, TP53 has been reported to be mutated in the majority of the cancers; however, in MM, it is very uncommon mutations in this gene. 24081673 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE The majority of malignant mesothelioma possesses the wild-type p53 gene with a homologous deletion of the INK4A/ARF locus containing the p14(ARF) and the p16(INK4A) genes. 22223137 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE The tumor suppressor function of Arf in MM was p53-independent, since MMs with loss of Arf retained functional p53. 21526190 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 AlteredExpression disease BEFREE Remarkably, one xenograft from MM-Z03E revealed overexpression of p53 and widely invasive growth. 17574962 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE The results suggest that the effects of asbestos on the p53 suppressor gene and Ha- and Ki-ras oncogenes in malignant mesothelioma are negligible. 12064559 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE We therefore evaluated the novel approach of adenoviral gene transfer of the proapoptotic Bcl-2 family member Bak in mesothelioma cancer cell lines, which are sensitive and resistant to adenoviral p53. 11135160 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE WT1 mutation in malignant mesothelioma and WT1 immunoreactivity in relation to p53 and growth factor receptor expression, cell-type transition, and prognosis. 9072005 1997
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE These results indicate that high levels of MDM2 are not responsible for inactivating the functions of wild-type p53 or the retinoblastoma gene product during the pathogenesis of malignant mesothelioma. 8932331 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE These results suggest that mdm2 might be involved in the inhibition of p53 in malignant mesothelioma. 8548129 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Lung carcinoma and malignant mesothelioma in patients exposed to Thorotrast: incidence, histology and p53 status. 7591226 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Immunoreactivity for p53 protein in malignant mesothelioma and non-neoplastic mesothelium. 1484318 1992