In various MM cell lines and regardless of calretinin expression levels, blocking of FAK signaling activated the Wnt signaling pathway and <i>vice versa</i>.
This is the first prospective cohort study to evaluate a detection of MM by calretinin and its combination with mesothelin up to about a year before clinical diagnosis.
Finally, CR downregulation via a lentiviral shRNA against CR (<i>CALB2</i>) resulted in a significantly reduced tumor formation <i>in vivo</i> in an orthotopic xenograft mouse model based on peritoneal MM cell injection.
Calretinin Functions in Malignant Mesothelioma Cells Cannot Be Replaced by the Closely Related Ca<sup>2+</sup>-Binding Proteins Calbindin-D28k and Parvalbumin.
Molecular markers like calretinin and mesothelin are promising tools to improve and supplement the diagnosis of MM and warrant further validation in a prospective study.
Assessment of potential predictors of calretinin and mesothelin to improve the diagnostic performance to detect malignant mesothelioma: results from a population-based cohort study.
These results demonstrate that downregulation of CR had a strong effect on the viability of MM cells and that CR is essential for cells derived from MM.
Both cell lines showed the immunologic profile characteristic for MM (i.e., expression of cytokeratin, CK18, calretinin, and vimentin in both phenotypes).
Although calretinin is a sensitive IHC marker for MM, it is not specific since it stained 30% of PA. Conversely, to differentiate between MM and PSCC, p63 and WT-1 are the best available markers.
In contrast, the "AP2-like" sequence does not play such a role in regulation of the CR gene transcription in adenocarcinoma and mesothelioma cancer cells.