Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.700 Biomarker disease CLINGEN Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. 23657012 2013
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.700 Biomarker disease CLINGEN Compromised BRCA1-PALB2 interaction is associated with breast cancer risk. 28319063 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.700 Biomarker disease CLINGEN The PALB2 1592delT mutation has a strong effect on familial breast cancer risk. 19383810 2009
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.700 Biomarker disease CLINGEN Our results show that mutation analysis of the PALB2 gene, including the analysis of LGRs, is primarily indicated in patients with HBC in case of their BRCA1 and BRCA2 negativity. 24136930 2013
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.700 Biomarker disease CLINGEN Mutation analysis of PALB2 in BRCA1 and BRCA2-negative breast and/or ovarian cancer families from Eastern Ontario, Canada. 25225577 2014
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.700 Biomarker disease CLINGEN Here we show, by screening for PALB2 mutations in Finland that a frameshift mutation, c.1592delT, is present at significantly elevated frequency in familial breast cancer cases compared with ancestry-matched population controls. 17287723 2007
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.700 Biomarker disease CLINGEN Clinical outcomes in women with breast cancer and a PALB2 mutation: a prospective cohort analysis. 25959805 2015
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.700 Biomarker disease CLINGEN Given this mutation prevalence and risk, consideration might be given to clinical testing of PALB2 by complete genomic sequencing for familial breast cancer patients with wild-type sequences at BRCA1 and BRCA2. 21285249 2011
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.700 Biomarker disease CLINGEN Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. 16793542 2006
Entrez Id: 7516
Gene Symbol: XRCC2
XRCC2 		0.530 Biomarker disease CLINGEN Homologous recombination deficiency leads to profound genetic instability in cells derived from Xrcc2-knockout mice. 14678973 2003
Entrez Id: 7516
Gene Symbol: XRCC2
XRCC2 		0.530 Biomarker disease CLINGEN Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice. 11118202 2000
Entrez Id: 7516
Gene Symbol: XRCC2
XRCC2 		0.530 Biomarker disease CLINGEN Rare mutations in XRCC2 increase the risk of breast cancer. 22464251 2012
Entrez Id: 7516
Gene Symbol: XRCC2
XRCC2 		0.530 Biomarker disease CLINGEN The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells. 10422536 1999
Entrez Id: 5892
Gene Symbol: RAD51D
RAD51D 		0.510 Biomarker disease CLINGEN RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors. 17942895 2007
Entrez Id: 5892
Gene Symbol: RAD51D
RAD51D 		0.510 Biomarker disease CLINGEN Identification and purification of two distinct complexes containing the five RAD51 paralogs. 11751635 2001
Entrez Id: 5892
Gene Symbol: RAD51D
RAD51D 		0.510 Biomarker disease CLINGEN Germline mutations in RAD51D confer susceptibility to ovarian cancer. 21822267 2011
Entrez Id: 5892
Gene Symbol: RAD51D
RAD51D 		0.510 Biomarker disease CLINGEN The homologous recombination protein RAD51D protects the genome from large deletions. 27924006 2017
Entrez Id: 5892
Gene Symbol: RAD51D
RAD51D 		0.510 Biomarker disease CLINGEN Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer. 28418444 2017
Entrez Id: 5892
Gene Symbol: RAD51D
RAD51D 		0.510 Biomarker disease CLINGEN Evidence for simultaneous protein interactions between human Rad51 paralogs. 10749867 2000
Entrez Id: 5892
Gene Symbol: RAD51D
RAD51D 		0.510 Biomarker disease CLINGEN Proteomics. Tissue-based map of the human proteome. 25613900 2015
Entrez Id: 5892
Gene Symbol: RAD51D
RAD51D 		0.510 Biomarker disease CLINGEN Extensive chromosomal instability in Rad51d-deficient mouse cells. 15781618 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.400 Biomarker disease CLINGEN Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications. 21542898 2011
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.400 Biomarker disease CLINGEN A risk of breast cancer in women - carriers of constitutional CHEK2 gene mutations, originating from the North - Central Poland. 24713400 2014
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.400 Biomarker disease CLINGEN Increased Risk for Other Cancers in Addition to Breast Cancer for CHEK2*1100delC Heterozygotes Estimated From the Copenhagen General Population Study. 26884562 2016
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.400 Biomarker disease CLINGEN hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. 10724175 2000