Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 80119
Gene Symbol: PIF1
PIF1
0.010 Biomarker disease BEFREE The Pif1 family of helicases is an evolutionarily conserved helicase family that is associated with familial breast cancer in humans. 28054200 2018
Entrez Id: 29116
Gene Symbol: MYLIP
MYLIP
0.010 AlteredExpression disease BEFREE Co-expression analysis of these genes with 9 miRs indicated that 49 differentially co-expressed miR-gene interactions changes in F-BC tumors as compared to those of NF-BC tumors. 25006670 2015
Entrez Id: 332
Gene Symbol: BIRC5
BIRC5
0.010 GeneticVariation disease BEFREE Two genotyped SNPs in BIRC5 were associated with familial breast cancer risk (top SNP rs2071214: per G allele OR 1.12, 95% CI 1.04-1.21, P = 0.002). 25586992 2015
Entrez Id: 3593
Gene Symbol: IL12B
IL12B
0.010 GeneticVariation disease BEFREE Association with TGFBR2 rs1367610 but not IL12B variants replicated using BCAC Asian samples and the independent Prospective Study of Outcomes in Sporadic versus Hereditary Breast Cancer Study and yielded a combined HR of 1.57 ((95% CI 1.28 to 1.94), P = 2.05 × 10⁻⁵) without study heterogeneity. 25849327 2015
Entrez Id: 22877
Gene Symbol: MLXIP
MLXIP
0.010 AlteredExpression disease BEFREE Co-expression analysis of these genes with 9 miRs indicated that 49 differentially co-expressed miR-gene interactions changes in F-BC tumors as compared to those of NF-BC tumors. 25006670 2015
Entrez Id: 57630
Gene Symbol: SH3RF1
SH3RF1
0.010 GeneticVariation disease BEFREE Cox-proportional hazard models were used to estimate hazard ratios (HR) in 536 patients from the POSH cohort (Prospective study of Outcomes in Sporadic versus Hereditary breast cancer) and 805 patients from the HEBCS cohort (Helsinki Breast Cancer Study). 25526632 2015
Entrez Id: 301
Gene Symbol: ANXA1
ANXA1
0.010 AlteredExpression disease BEFREE ANXA1 is overexpressed in familial breast cancer patients with BRCA1/2 mutations and correlated with poor prognosis features: triple negative and poorly differentiated tumors. 26137966 2015
Entrez Id: 220972
Gene Symbol: MARCH8
MARCH8
0.010 AlteredExpression disease BEFREE Co-expression analysis of these genes with 9 miRs indicated that 49 differentially co-expressed miR-gene interactions changes in F-BC tumors as compared to those of NF-BC tumors. 25006670 2015
Entrez Id: 10721
Gene Symbol: POLQ
POLQ
0.010 GeneticVariation disease BEFREE A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case-control study. 25409685 2015
Entrez Id: 216
Gene Symbol: ALDH1A1
ALDH1A1
0.010 AlteredExpression disease BEFREE The aim of this study was to determine the association between CD44(+)/CD24(-/low) and ALDH1 expression with clinical-pathologic tumor characteristics, tumor molecular subtype, and survival in a well characterized collection of familial breast cancer cases. 23813303 2014
Entrez Id: 100133941
Gene Symbol: CD24
CD24
0.010 Biomarker disease BEFREE The CD44(+)/CD24(-/low) and ALDH1+ phenotypes were identified in 16% and 15% of the familial breast cancer cases, respectively, and associated with high-tumor grade, a high-mitotic count, and component features of the medullary type of breast cancer. 23813303 2014
Entrez Id: 2072
Gene Symbol: ERCC4
ERCC4
0.010 GeneticVariation disease BEFREE Mutation analysis of the ERCC4/FANCQ gene in hereditary breast cancer. 24465539 2014
Entrez Id: 285
Gene Symbol: ANGPT2
ANGPT2
0.010 Biomarker disease BEFREE Moreover, a positive correlation between Ang-2 and VEGF was found in both the familial breast cancer group (BRCA carriers: r=0.83; P<0.0001 and BRCAX: r=0.58; P=0.008) and in TNBC (r=0.62; P=0.007). 23232696 2013
Entrez Id: 7474
Gene Symbol: WNT5A
WNT5A
0.010 Biomarker disease BEFREE The aim of this study was to investigate the expression of 2 members of the Wnt family (WIF-1 and Wnt5a) in sporadic and hereditary breast cancer tissues. 23417837 2013
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.010 GeneticVariation disease BEFREE Seven of the 19 markers were significant in a multivariate predictive model of familial breast cancer in AJ women, three novel SNPs [rs17663555(5q13.2), rs566164(6q21), and rs11075884(16q22.2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator characteristic curve) of 0.74. 23354978 2013
Entrez Id: 27324
Gene Symbol: TOX3
TOX3
0.010 GeneticVariation disease BEFREE Seven of the 19 markers were significant in a multivariate predictive model of familial breast cancer in AJ women, three novel SNPs [rs17663555(5q13.2), rs566164(6q21), and rs11075884(16q22.2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator characteristic curve) of 0.74. 23354978 2013
Entrez Id: 406952
Gene Symbol: MIR17
MIR17
0.010 Biomarker disease BEFREE In conclusion, the present data suggest the involvement of RASSF1A in familial male BC, while miR17 and let-7a seem to be implied in familial female BC. 23160909 2013
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.010 AlteredExpression disease BEFREE VEGF, HIF-1α expression and MVD as an angiogenic network in familial breast cancer. 23326384 2013
Entrez Id: 7010
Gene Symbol: TEK
TEK
0.010 Biomarker disease BEFREE Angiogenetic axis angiopoietins/Tie2 and VEGF in familial breast cancer. 23232696 2013
Entrez Id: 9577
Gene Symbol: BABAM2
BABAM2
0.010 AlteredExpression disease BEFREE In this retrospective study, we show that expression levels of BRE, which encodes a member of the BRCA1 DNA damage repair complex, predicted disease-free survival (DFS) in non-familial breast cancer patients. 22706632 2013
Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
0.010 AlteredExpression disease BEFREE Tumoral lymphocytic infiltration and expression of the chemokine CXCL10 in breast cancers from the Ontario Familial Breast Cancer Registry. 23213058 2013
Entrez Id: 284
Gene Symbol: ANGPT1
ANGPT1
0.010 Biomarker disease BEFREE Vascular endothelial growth factor (VEGF) and Angiopoietins (Ang-1, Ang-2) have a pivotal role in tumor angiogenesis but few data regarding their role in hereditary breast cancer are available. 23232696 2013
Entrez Id: 738
Gene Symbol: VPS51
VPS51
0.010 Biomarker disease BEFREE Moreover, a positive correlation between Ang-2 and VEGF was found in both the familial breast cancer group (BRCA carriers: r=0.83; P<0.0001 and BRCAX: r=0.58; P=0.008) and in TNBC (r=0.62; P=0.007). 23232696 2013
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.010 PosttranslationalModification disease BEFREE In the present study RASSF1A and RAR beta promoter methylation and miR17, miR21, miR 124, and let-7a expression were investigated to highlight possible differences of epigenetic regulation between male and female familial BC, also in comparison with sporadic BC. 23160909 2013
Entrez Id: 7108
Gene Symbol: TM7SF2
TM7SF2
0.010 Biomarker disease BEFREE Vascular endothelial growth factor (VEGF) and Angiopoietins (Ang-1, Ang-2) have a pivotal role in tumor angiogenesis but few data regarding their role in hereditary breast cancer are available. 23232696 2013