| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.100 | GeneticVariation | disease | BEFREE | The entire TP53 coding sequence, including intron-exon boundaries and UTRs, was analyzed via DHPLC and direct sequencing, and the association of TP53 genotypes with BC risk and with individual lifetime exposures to reproductive factors was investigated with statistical tools. | 30796655 | 2019 | ||||
|
0.100 | GeneticVariation | disease | BEFREE | The intronic G13964C variant in p53 is not a high-risk mutation in familial breast cancer in Australia. | 11597326 | 2001 | ||||
|
0.100 | GeneticVariation | disease | BEFREE | The most important cause of developing hereditary breast cancer is germline mutations occurring in breast cancer (BCs) susceptibility genes, for example, BRCA1, BRCA2, TP53, CHEK2, PTEN, ATM, and PPM1D. | 30552672 | 2019 | ||||
|
0.100 | Biomarker | disease | BEFREE | The most well-established breast molecular markers with prognostic and/or therapeutic value like hormone receptors, HER-2 oncogene, Ki-67, and p53 proteins, and the genes for hereditary breast cancer will be presented. | 24591761 | 2014 | ||||
|
0.100 | GeneticVariation | disease | BEFREE | The present case-control study investigated the association of this SNP (IVS1+309) with the risk and the age of onset of familial breast cancer in patients with unknown p53 mutation status. | 16423991 | 2006 | ||||
|
0.100 | GeneticVariation | disease | BEFREE | To estimate the prevalence of TP53 mutations in familial breast cancer, constant denaturant gel electrophoresis (CDGE) was used to screen exons 5-8 of the TP53 gene for germline mutations. | 9099970 | 1997 | ||||
|
0.100 | GeneticVariation | disease | BEFREE | We performed TP53 mutation analysis and genomewide analysis of loss of heterozygosity and allelic imbalance on DNA from isolated neoplastic epithelial and stromal cells from 43 patients with hereditary breast cancer and 175 patients with sporadic breast cancer. | 18094375 | 2007 |