| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | After multivariate logistic regression analysis, BRCAx tumors are more likely ER positive (P = 0.001) and HER2 positive (P = 0.047) in comparison to BRCA1. | 25736863 | 2015 | ||||
|
0.080 | Biomarker | disease | BEFREE | We found HER-2/neu negativity and BRCA1 positivity associated with familial breast cancer. | 23232912 | 2013 | ||||
|
0.080 | Biomarker | disease | BEFREE | We found that a marker signature comprising human epidermal growth factor receptor 2 (HER2) negativity, Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) negativity and BRCA1 positivity (designated 'triple-biomarker' signature) is frequently associated with familial breast cancer and promises to be a reliable test in its molecular characterization. | 21285147 | 2011 | ||||
|
0.080 | Biomarker | disease | BEFREE | Features of hereditary breast cancer include an early age-of-onset and over-representation of the 'triple-negative' phenotype (negative for estrogen-receptor, progesterone-receptor and HER2). | 19298662 | 2009 | ||||
|
0.080 | Biomarker | disease | BEFREE | 655Val and 1170Pro ERBB2 SNPs in familial breast cancer risk and BRCA1 alterations. | 17452776 | 2007 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The rare ERBB2 variant Ile654Val is associated with an increased familial breast cancer risk. | 15550452 | 2005 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Although the overexpression rate of HER-2/neu oncoprotein of familial breast cancer was not significantly higher than that of the non-familial group, it is appropriate to evaluate the rate of HER-2/neu overexpression according to the histological type of breast cancers from familial breast cancer and non-familial breast cancer. | 11416960 | 2001 | ||||
|
0.080 | Biomarker | disease | BEFREE | Other cancer-related genes (including myc, c-erbB2, Tsg101 and Mdgi) are involved in breast carcinogenesis, but they do not give rise to familial breast cancer syndromes. | 10671920 | 2000 |