Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 GeneticVariation disease BEFREE These variants were found in genes associated with known or suspected BC predisposition (PALB2, BARD1, CHEK2, RAD51C and FANCA) or in predisposing genes linked to other cancer types but not well-studied in the context of familial BC (EXO1, RECQL4, CCNH, MUS81, TDP1, DCLRE1A, DCLRE1C, PDE11A and RINT1) and genes associated with different hereditary syndromes but not yet clearly associated with familial cancer syndromes (ABCC11, BBS10, CD96, CYP1A1, DHCR7, DNAH11, ESCO2, FLT4, HPS6, MYH8, NME8 and TTC8). 30947698 2019
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 GeneticVariation disease BEFREE Hence, our approach allowed us to specify BC relative risks associated with deleterious-predicted variants in PALB2, ATM and CHEK2 and to add MAST1, POLH, RTEL1 and FANCI to the list of DNA repair genes possibly involved in BC susceptibility. 30303537 2019
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 Biomarker disease BEFREE The risk attributed to some of these genes (e.g., CDKN2A and PALB2 for BC) was similar to that observed for BRCA2. 30733081 2019
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 GeneticVariation disease BEFREE Using Exome Aggregation Consortium control data, we confirm significant associations of heterozygous germ line mutations with BC for ATM (OR: 3.63, 95%CI: 2.67-4.94), CDH1 (OR: 17.04, 95%CI: 3.54-82), CHEK2 (OR: 2.93, 95%CI: 2.29-3.75), PALB2 (OR: 9.53, 95%CI: 6.25-14.51), and TP53 (OR: 7.30, 95%CI: 1.22-43.68). 29522266 2018
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 GeneticVariation disease BEFREE In five patients (5 of 83; 6% of cohort), we detected causative pathogenic variants in established hereditary breast cancer susceptibility genes (i.e., PALB2, CHEK2, ATM). 30086788 2018
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 Biomarker disease CLINGEN Compromised BRCA1-PALB2 interaction is associated with breast cancer risk. 28319063 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 GeneticVariation disease BEFREE PALB2 c.1676A > G (rs152451A/G) and c.2993C > T (rs45551636C/T) variants were significantly associated with increased BC risk only in cases with a strong family history of BC (OR = 1.9 [CI 95% 1.3-2.8] p < 0.01 and OR = 3.3 [CI 95% 1.4-7.3] p < 0.01, respectively). 25636233 2015
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 Biomarker disease BEFREE Most of the previous studies of PALB2 have focused on familial breast cancer cases with normal/wild-type BRCA1 and BRCA2 (BRCAx). 25833210 2015
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 GeneticVariation disease BEFREE PALB2 gene is mutated in about 1-2% of familial breast cancer as well as in 3-4% of familial pancreatic cancer cases. 25666743 2015
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 Biomarker disease CLINGEN Clinical outcomes in women with breast cancer and a PALB2 mutation: a prospective cohort analysis. 25959805 2015
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 GeneticVariation disease BEFREE Mutations in PALB2 are less common than BRCA1 and BRCA2 in familial breast cancer patients. 25794774 2015
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 SusceptibilityMutation disease ORPHANET Loss-of-function mutations in PALB2 are an important cause of hereditary breast cancer, with respect both to the frequency of cancer-predisposing mutations and to the risk associated with them. 25099575 2014
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 Biomarker disease BEFREE PALB2 sequencing in Italian familial breast cancer cases reveals a high-risk mutation recurrent in the province of Bergamo. 24556926 2014
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 GeneticVariation disease BEFREE Loss-of-function mutations in PALB2 are an important cause of hereditary breast cancer, with respect both to the frequency of cancer-predisposing mutations and to the risk associated with them. 25099575 2014
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 Biomarker disease CLINGEN Mutation analysis of PALB2 in BRCA1 and BRCA2-negative breast and/or ovarian cancer families from Eastern Ontario, Canada. 25225577 2014
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 GeneticVariation disease BEFREE These results suggest that PALB2 mutations occur at a frequency of ~1% in patients with hereditary breast cancer. 24415441 2014
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 Biomarker disease GENOMICS_ENGLAND Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. 23657012 2013
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 Biomarker disease BEFREE Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer. 23650262 2013
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 GeneticVariation disease BEFREE Heterozygous mutations in the PALB2 hereditary breast cancer predisposition gene impact on the three-dimensional nuclear organization of patient-derived cell lines. 23341105 2013
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 Biomarker disease CLINGEN Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. 23657012 2013
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 Biomarker disease CLINGEN Our results show that mutation analysis of the PALB2 gene, including the analysis of LGRs, is primarily indicated in patients with HBC in case of their BRCA1 and BRCA2 negativity. 24136930 2013
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 GeneticVariation disease BEFREE Germline mutations in PALB2 have been identified in approximately 1% of familial breast cancer and 3-4% of familial pancreatic cancer. 23935836 2013
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 GeneticVariation disease BEFREE Our results show that mutation analysis of the PALB2 gene, including the analysis of LGRs, is primarily indicated in patients with HBC in case of their BRCA1 and BRCA2 negativity. 24136930 2013
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 GeneticVariation disease BEFREE It has been demonstrated that monoallelic PALB2 (Partner and Localizer of BRCA2) gene mutations predispose to familial breast cancer. 22052327 2012
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
0.700 Biomarker disease BEFREE Other genes that include CHEK2, PTEN, TP53, ATM, STK11/LKB1, CDH1, NBS1, RAD50, BRIP1 and PALB2 have been described to be high or moderate penetrance breast cancer susceptibility genes, all contributing to the hereditary breast cancer spectrum. 21336636 2011