Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE The expressions of SMYD3, caspase-3, and matrix metallopeptidase-2 (MMP-2) were detected in pancreatic cancer and non-tumor tissues by immunohistochemistry. 31441002 2020
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE TSPAN1 upregulates MMP2 to promote pancreatic cancer cell migration and invasion via PLCγ. 30720116 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE The anti-invasive effect of CL for BxPC-3 cells was found to occur through the inhibition of MMP2, MMP9, and MMP14. 30803757 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE Our study demonstrates that the YY1/FER/STAT3/MMP2 axis is associated with the progression of pancreatic cancer and may provide a new therapeutic target for the treatment of pancreatic cancer. 31404611 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Moreover, the anti-metastasis role of CSN5 silence was reversed by MMP2 overexpression, whereas knockdown of MMP2 decreased PC metastasis driven by upregulation of CSN5. 30352219 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Then MMP2 and ACTA2 expression profiles in pancreatic cancer were obtained from UCSC (University of California, Santa Cruz) and SurvExpress. 30466735 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Here, we report ARHGAP4 as a new regulator of the β-catenin pathway that regulates cell invasion and migration of pancreatic cancer as well as the downstream effector MMP2 and MMP9 expression in vitro. 30958531 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE Presented findings suggest higher usefulness of TIMP-2 than MMP-2 as potential biomarker in the diagnosis of PC patients, however more studies on large population are needed to support our results. 30719232 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Rosmarinic inhibits cell proliferation, invasion and migration via up-regulating miR-506 and suppressing MMP2/16 expression in pancreatic cancer. 31060006 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease CTD_human Pancreatic carcinoma cells colonizing the liver modulate the expression of their extracellular matrix genes. 30603057 2018
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE The expression of MMP-2 and MMP-9 is associated with angiogenesis in pancreatic cancer. 26866436 2018
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Elevated MMP-2 levels were observed in blood of pancreatic cancer patients which correlated with its tissue expression. 29355139 2017
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE The Transient Receptor Potential Melastatin 7 Channel Regulates Pancreatic Cancer Cell Invasion through the Hsp90α/uPA/MMP2 pathway. 28284058 2017
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Knockdown of TM4SF1 inhibited the migration and invasion of pancreatic cancer cells by regulating the expression and activity of MMP-2 and MMP-9, which suggests that TM4SF1 may play a significant role in metastasis in pancreatic cancer. 27459514 2016
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE Overexpression of miR-29c suppresses pancreatic cancer liver metastasis in a nude mouse orthotopic implantation model. miR-29c expression was associated with metastasis and pancreatic cancer patient survival. miR-29c plays an important role in mediating pancreatic cancer metastasis to the liver by targeting MMP2. 25863127 2015
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE These data indicate that overexpressed miR-221/222 may play an oncogenic role in pancreatic cancer by inducing the expression of MMP-2 and MMP-9, thus leading to cancer cell invasion. 25883224 2015
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE In conclusion, the present study reveals that the increased expression of OCT4 is correlated with the differentiation of pancreatic cancer, while knockdown of OCT4 suppresses the growth and invasion of pancreatic cancer cells through inhibition of AKT pathway‑mediated PCNA and MMP‑2 expression, suggesting that OCT4 might serve as a potential therapeutic target for the treatment of pancreatic cancer. 25017645 2014
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE M-CTX-Fc decreased MMP-2 release into the media of PANC-1 cells in a dose-dependent manner. 24511528 2014
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE In this study, analysis of SDF-1α, CXCR4 and MMP-2 expression in pancreatic cancer and adjacent tissue samples from ten patients revealed that all three proteins are overexpressed in human pancreatic cancer. 23712777 2013
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Moreover, establishment of pancreatic cancer in mice exposed to chronic stress was accompanied by up-regulation of the expression of MMP-2, MMP-9, and VEGF, mediated by a HIF- 1α-dependent β-AR signaling pathway. 23745588 2013
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 PosttranslationalModification disease BEFREE Activation and blocking of the Stat3 signaling pathway can affect invasion ability and expression of the VEGF and MMP-2 genes in pancreatic cancer cells. 20482858 2010
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE To investigate the inhibitory effects of RNA interference (RNAi) on expression of matrix metalloproteinase-2 (MMP-2) gene and invasiveness and adhesion of human pancreatic cancer cell line, BxPC-3. 19266599 2009
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE These data suggest that BMP signaling, through Smad1 induction and upregulation of MMP-2, is an important mediator of pancreatic cancer invasiveness and a potential therapeutic target for treating this deadly disease. 19056927 2009
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Summary, our studies indicate for the first time that NRAGE could suppress metastasis of melanoma and pancreatic cancer probably through downregulation of MMP-2. 17140727 2007
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Glucose transporter-1 gene expression is associated with pancreatic cancer invasiveness and MMP-2 activity. 15349101 2004