Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Here, we report ARHGAP4 as a new regulator of the β-catenin pathway that regulates cell invasion and migration of pancreatic cancer as well as the downstream effector MMP2 and MMP9 expression in vitro. 30958531 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE By combination of results from expression, survival and correlation analysis demonstrated that MMP9/ITGB1-miR-29b-3p-HCP5 competing endogenous RNA (ceRNA) sub-network was linked to prognosis of pancreatic cancer. 31061236 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE Therapeutic efficacy of anti-MMP9 antibody in combination with nab-paclitaxel-based chemotherapy in pre-clinical models of pancreatic cancer. 30941918 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE The expression of MMP-2 and MMP-9 is associated with angiogenesis in pancreatic cancer. 26866436 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE CCL21 regulates pancreatic cancer immunity possibly through governing the expression of a panel of tumor-associated genes, including MMP-9. 29687228 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Knockdown of TM4SF1 inhibited the migration and invasion of pancreatic cancer cells by regulating the expression and activity of MMP-2 and MMP-9, which suggests that TM4SF1 may play a significant role in metastasis in pancreatic cancer. 27459514 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE These data indicate that overexpressed miR-221/222 may play an oncogenic role in pancreatic cancer by inducing the expression of MMP-2 and MMP-9, thus leading to cancer cell invasion. 25883224 2015
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease CTD_human Exocrine pancreatic carcinogenesis and autotaxin expression. 22952646 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Keratinocyte growth factor induces matrix metalloproteinase-9 expression and correlates with venous invasion in pancreatic cancer. 22159401 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Slug, E-cadherin, and MMP-9 expression in pancreatic cancer was significantly associated with lymph node metastases and we found a significant correlation between Slug and MMP-9 expression; however, no significant correlation was observed between Slug and E-cadherin expression. 21283078 2011
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Resveratrol inhibited the proliferation of 4 different human PaCa cell lines, synergized the apoptotic effects of gemcitabine, inhibited the constitutive activation of NF-kappaB and expression of bcl-2, bcl-xL, COX-2, cyclin D1 MMP-9 and VEGF. 19908231 2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE The combination of VNN1 and MMP9 showed the best discrimination of pancreatic cancer-associated diabetes from type 2 diabetes. 20571492 2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE Down-regulation of DR3 in PaC cells was found to down regulate activated pNF-kappaB/p65, pIkBalpha/beta kinases (pIKK's), MMP9 and XIAP that mostly impart chemoresistance in PaC. 19670328 2009
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE Gli1 contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase-9 activation. 18410405 2008
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE TRAIL can stimulate the expression of uPA, IL-8, MMP-7 and MMP-9 in pancreatic cancer cell lines, especially in Colo357wt. 18397859 2008
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE Our findings indicated that NF-kappaB-mediated MMP-9 and uPA induction was responsible for EGF-induced invasiveness in these pancreatic cancer cell lines and implicate that such anti-NF-kappaB therapy as the use of NF-kappaB inhibitors may contribute to the reduction of invasiveness of pancreatic cancer. 16340751 2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. 16510599 2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE Tumor-associated trypsinogen (TAT), urokinase-type plasminogen activator (u-PA), matrix metalloproteinase-2 (MMP-2), and MMP-9 each play a dominant role in the degradation of extracellular matrix (ECM) during the invasion process of pancreatic cancer. 15257104 2004
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE These findings suggest that GDNF modulates MMP-9 expression and activation, and this may promote pancreatic cancer invasion. 12947332 2003
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Pancreatic cancer is no exception; MMP-2 and MMP-9 show high levels of expression in clinical and experimental models. 12167581 2002
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE Steady-state levels of transcripts encoding extracellular matrix proteins, MMP-2 (72-kDa collagenase IV), MMP-9 (92-kDa collagenase type IV), TIMP-1 and TIMP-2 were elevated in the majority of pancreatic-cancer tissue samples as compared to control pancreatic tissue. 7635566 1995