Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 952
Gene Symbol: CD38
CD38
0.080 Biomarker disease BEFREE A combination of germline genetic characteristics, clinical features (eg, advanced Rai stage), biologic (ζ-associated protein-70(+), CD38(+), CD49d(+)) and somatic genetic (del17p13.1 or del11q23.1) characteristics of CLL B cells, and certain CLL therapies are associated with higher risk of RS. 24421328 2014
Entrez Id: 952
Gene Symbol: CD38
CD38
0.080 GeneticVariation disease BEFREE Germline polymorphisms in genes related to CD38, LRF4, and BCL-2 have been implicated in the development of RS. 25218362 2014
Entrez Id: 952
Gene Symbol: CD38
CD38
0.080 GeneticVariation disease BEFREE Specific risk factors for the development of Richter's transformation in a patient with CLL have yet to be identified; however, TP53 disruption, c-MYCabnormalities, unmutated immunoglobulin heavy chain (IGHV) < 2%, non-del13q cytogenetics, CD38 gene polymorphisms, stereotypy, and VH4-39 gene usage may predispose to Richter's transformation. 23413591 2012
Entrez Id: 952
Gene Symbol: CD38
CD38
0.080 Biomarker disease BEFREE According to correlation analysis, a high level of lactate dehydrogenase (LDH) and CD38 positivity were found to be independent predictors of transformation to RS. 22329349 2012
Entrez Id: 952
Gene Symbol: CD38
CD38
0.080 GeneticVariation disease BEFREE Importantly, although some risk factors predict both CLL progression and transformation to RS, others (CD38 genotype, absence of del13q14, IGHV4-39 usage, stereotyped B-cell receptor) appear to specifically predict RS. 21417856 2011
Entrez Id: 952
Gene Symbol: CD38
CD38
0.080 GeneticVariation disease BEFREE The CD38 gene shows genetic differences in the promoter region, some of which represent an independent risk for Richter transformation. 20817095 2010
Entrez Id: 952
Gene Symbol: CD38
CD38
0.080 GeneticVariation disease BEFREE CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome? 18424664 2008
Entrez Id: 952
Gene Symbol: CD38
CD38
0.080 AlteredExpression disease BEFREE Multivariate analysis, performed separately for biological and clinical variables, identified CD38 expression [Hazard ratio (HR) = 4.26; P = 0.018], IGHV4-39 usage (HR = 4.29; P = 0.018), and lymph node size >/=3 cm (HR = 9.07; P < 0.001) as independent RS prognosticators. 18492108 2008