| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.380 | GeneticVariation | disease | BEFREE | <i>PTPN11</i> gain-of-function mutation is the most common mutation found in patients with juvenile myelomonocytic leukemia and DNMT3A loss occurs in over 20% of acute myeloid leukemia patients. | 29464054 | 2018 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia. | 29227812 | 2018 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | Chronic myelomonocytic leukemia with double-mutations in DNMT3A and FLT3-ITD treated with decitabine and sorafenib. | 28102729 | 2017 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | DNMT3A mutations are associated with inferior overall and leukemia-free survival in chronic myelomonocytic leukemia. | 27733013 | 2017 | ||||
|
0.380 | Biomarker | disease | CTD_human | The genomic landscape of juvenile myelomonocytic leukemia. | 26457647 | 2015 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | We explored prognostic implications of gene mutations such as DNMT3A, issues related to the classification of AML cases with the NPM1 mutation, and myelodysplasia-related changes arising from chronic myelomonocytic leukemia after a short latency interval. | 26071459 | 2015 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells. | 24497509 | 2014 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | By comparison, our screening of juvenile myelomonocytic leukemia cases showed mutations in ASXL1 (4%), CBL (10%), and RAS (6%) but not in IDH1/2, TET2, EZH2, DNMT3A or the three spliceosomal genes. | 22773603 | 2013 | ||||
|
0.380 | Biomarker | disease | BEFREE | Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. | 21828135 | 2011 |