| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | disease | BEFREE | Utility of JAK2 V617F allelic burden in distinguishing chronic myelomonocytic Leukemia from Primary myelofibrosis with monocytosis. | 30447300 | 2019 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Chronic Myelomonocytic Leukemia With Fibrosis Is a Distinct Disease Subset With Myeloproliferative Features and Frequent JAK2 p.V617F Mutations. | 29596070 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Finally, we found that primary cells from a patient with KRAS-mutant juvenile myelomonocytic leukemia displayed reduced colony formation in response to JAK2 inhibition. | 27418650 | 2016 | ||||
|
0.080 | Biomarker | disease | BEFREE | In vitro and in vivo effects of JAK2 inhibition in chronic myelomonocytic leukemia. | 27157043 | 2016 | ||||
|
0.080 | Biomarker | disease | BEFREE | Genetic typing of CBL, ASXL1, RUNX1, TET2 and JAK2 in juvenile myelomonocytic leukaemia reveals a genetic profile distinct from chronic myelomonocytic leukaemia. | 20955399 | 2010 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Other mutations of putative pathogenetic relevance in MPDs include: JAK2V617F in PV, ET, and PMF; JAK2 exon 12 mutations in PV; MPLW515L/K in PMF and ET; KITD816V in SM; FIP1L1-PDGFRA in CEL-SM; rearrangements of PDGFRB in CEL-CMML and FGFR1 in stem cell leukemia-lymphoma syndrome; and RAS/PTPN11/NF1 mutations in JMML. | 17351342 | 2007 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | In addition, Bcr/Abl-negative classic myeloproliferative disorders are characterized by recurrent JAK2(V617F) mutations, whereas other mutations affecting the RAS signaling pathway molecules have been associated with juvenile myelomonocytic leukemia. | 16781478 | 2006 | ||||
|
0.080 | GeneticVariation | disease | LHGDN | JAK2 Val617Phe activating tyrosine kinase mutation in juvenile myelomonocytic leukemia. | 16079889 | 2005 |