Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.380 | Biomarker | disease | BEFREE | Somatic cell mutations and chromosomal abnormalities, including those of RUNX1, are observed in myelodysplastic syndrome, acute myeloid leukemia, acute lymphoblastic leukemia, and chronic myelomonocytic leukemia at a high frequency. | 29883054 | 2018 | ||||
|
0.380 | Biomarker | disease | CTD_human | The genomic landscape of juvenile myelomonocytic leukemia. | 26457647 | 2015 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | Biological Activities of RUNX1 Mutants Predict Secondary Acute Leukemia Transformation from Chronic Myelomonocytic Leukemia and Myelodysplastic Syndromes. | 25840971 | 2015 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | Here we demonstrate that runx1 deletion in mice induces the persistence of MYH10 in platelets, and a similar persistence was observed in platelets of patients with constitutional (familial platelet disorder/acute myeloid leukemia) or acquired (chronic myelomonocytic leukemia) RUNX1 mutations. | 22677128 | 2012 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | RUNX1 mutations are frequent in chronic myelomonocytic leukemia and mutations at the C-terminal region might predict acute myeloid leukemia transformation. | 19282830 | 2009 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes. | 18925961 | 2008 | ||||
|
0.380 | GeneticVariation | disease | LHGDN | Mutation analysis of AML1 gene in pediatric primary myelodysplastic syndrome and juvenile myelomonocytic leukemia. | 17935781 | 2008 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | Studies on the regulation of Evi-1 expression in CD34+ cells will elucidate its function in progenitor cells and clarify its possible role in the pathogenesis of JMML. | 9432037 | 1997 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | Overall, our results suggest that the EVI-1 gene may be normally expressed in early hematopoietic progenitor cells and that in JMML patients an expansion of the EVI-1 positive cell population can be revealed within the clonogenic progenitor pool. | 9447818 | 1997 |