Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 55083
Gene Symbol: KIF26B
KIF26B
0.100 GeneticVariation disease GWASCAT Identification of a 3'-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Study. 30251476 2019
Entrez Id: 51384
Gene Symbol: WNT16
WNT16
0.100 GeneticVariation disease GWASCAT Identification of a 3'-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Study. 30251476 2019
Entrez Id: 4000
Gene Symbol: LMNA
LMNA
0.100 GeneticVariation disease GWASCAT Identification of a 3'-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Study. 30251476 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.040 Biomarker disease BEFREE In African Americans, ischemic cardiomyopathy (ICM) and lack of therapy with an angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) were associated with increased mortality. 29570216 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.040 Biomarker disease BEFREE LVEDV >158 mL and no use of angiotensin-converting-enzyme inhibitor/angiotensin receptor blocker were independent predictors of recurrences of VT/VF in ICM patients but not in DCM patients. 30038875 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.040 AlteredExpression disease BEFREE The sensitive technique of quantitative reverse transcriptase polymerase chain reaction was used to determine the level of mRNA expression of ACE and ACE2 in human ventricular myocardium from donors with non-diseased hearts (n = 9), idiopathic dilated cardiomyopathy (IDC, n = 11) and ischemic cardiomyopathy (ICM, n = 12). 15151696 2004
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.040 GeneticVariation disease BEFREE Compared with the DD frequency in the control population, the frequency of the ACE DD genotype was 48% higher in individuals with idiopathic dilated cardiomyopathy (p = 0.008) and 63% higher in subjects with ischaemic cardiomyopathy (p = 0.008), suggesting that an ACE gene variant may contribute to the pathogenesis of both types of cardiomyopathy. 8105309 1993
Entrez Id: 799
Gene Symbol: CALCR
CALCR
0.030 GeneticVariation disease BEFREE We aimed to compare incidence of appropriate sustained ventricular arrhythmia (SVA) and device therapy in ischemic cardiomyopathy (ICM) vs NICM ICD and/or cardiac resynchronization therapy (CRT-D) patients. 31165517 2019
Entrez Id: 811
Gene Symbol: CALR
CALR
0.030 GeneticVariation disease BEFREE We aimed to compare incidence of appropriate sustained ventricular arrhythmia (SVA) and device therapy in ischemic cardiomyopathy (ICM) vs NICM ICD and/or cardiac resynchronization therapy (CRT-D) patients. 31165517 2019
Entrez Id: 6535
Gene Symbol: SLC6A8
SLC6A8
0.030 GeneticVariation disease BEFREE We aimed to compare incidence of appropriate sustained ventricular arrhythmia (SVA) and device therapy in ischemic cardiomyopathy (ICM) vs NICM ICD and/or cardiac resynchronization therapy (CRT-D) patients. 31165517 2019
Entrez Id: 6535
Gene Symbol: SLC6A8
SLC6A8
0.030 Biomarker disease BEFREE When further stratified according to aetiology, CRT-D was associated with a lower total mortality (HR 0.62), total mortality or HF hospitalization (HR 0.63), and total mortality or hospitalization for MACE (HR 0.59) (all P < 0.001) in patients with ischaemic cardiomyopathy (ICM). 29697764 2018
Entrez Id: 811
Gene Symbol: CALR
CALR
0.030 GeneticVariation disease BEFREE Fifteen patients (13 male) with permanent AF (mean age 76 ± 7 years; left ventricular ejection fraction 33 ± 7%; 7 with ischemic cardiomyopathy; mean QRS duration 178 ± 25 ms) were selected as candidates for CRT. 29627954 2018
Entrez Id: 811
Gene Symbol: CALR
CALR
0.030 Biomarker disease BEFREE When further stratified according to aetiology, CRT-D was associated with a lower total mortality (HR 0.62), total mortality or HF hospitalization (HR 0.63), and total mortality or hospitalization for MACE (HR 0.59) (all P < 0.001) in patients with ischaemic cardiomyopathy (ICM). 29697764 2018
Entrez Id: 6535
Gene Symbol: SLC6A8
SLC6A8
0.030 GeneticVariation disease BEFREE Fifteen patients (13 male) with permanent AF (mean age 76 ± 7 years; left ventricular ejection fraction 33 ± 7%; 7 with ischemic cardiomyopathy; mean QRS duration 178 ± 25 ms) were selected as candidates for CRT. 29627954 2018
Entrez Id: 799
Gene Symbol: CALCR
CALCR
0.030 GeneticVariation disease BEFREE Fifteen patients (13 male) with permanent AF (mean age 76 ± 7 years; left ventricular ejection fraction 33 ± 7%; 7 with ischemic cardiomyopathy; mean QRS duration 178 ± 25 ms) were selected as candidates for CRT. 29627954 2018
Entrez Id: 799
Gene Symbol: CALCR
CALCR
0.030 Biomarker disease BEFREE When further stratified according to aetiology, CRT-D was associated with a lower total mortality (HR 0.62), total mortality or HF hospitalization (HR 0.63), and total mortality or hospitalization for MACE (HR 0.59) (all P < 0.001) in patients with ischaemic cardiomyopathy (ICM). 29697764 2018
Entrez Id: 6523
Gene Symbol: SLC5A1
SLC5A1
0.020 Biomarker disease BEFREE We examined the effects of KGA-2727, a selective SGLT1 inhibitor, on myocardial infarction (MI)-induced ischemic cardiomyopathy. 31776072 2020
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.020 AlteredExpression disease BEFREE Low-energy extracorporeal shock wave (SW) improves ventricular function in ischemic cardiomyopathy through the upregulation of vascular endothelial growth factor (VEGF). 30617840 2019
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.020 AlteredExpression disease BEFREE Pioglitazone strengthen therapeutic effect of adipose-derived regenerative cells against ischemic cardiomyopathy through enhanced expression of adiponectin and modulation of macrophage phenotype. 30902059 2019
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.020 AlteredExpression disease BEFREE Confirmatory western bolt analysis demonstrated that SDHB was down-regulated in both ICM and DCM hearts, while UQCRQ, GLUT4 and adiponectin were up-regulated in ICM hearts. 31275164 2019
Entrez Id: 2697
Gene Symbol: GJA1
GJA1
0.020 AlteredExpression disease BEFREE Indicators of sympathetic neural remodeling and cardiac remodeling were detected to further explore the related mechanisms.Four weeks after MI, rats in the ARNi group exhibited low susceptibility of VAs in comparison with that in the MI group, which was coincident with the attenuation of sympathetic nerve remodeling, amelioration of cardiac fibrosis, and regulation of Cx43 expression.ARNi is effective in reducing VAs in rats with ischemic cardiomyopathy, which is associated with attenuating sympathetic nerve remodeling and myocardial fibrosis. 31484876 2019
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
0.020 Biomarker disease BEFREE Thus, we conclude that VPO1 is a crucial regulator of cardiac fibrosis after MI by mediating HOCl/Smad2/3 and ERK1/2 signaling pathways, implying a promising therapeutic target in ischemic cardiomyopathy. 30844643 2019
Entrez Id: 6523
Gene Symbol: SLC5A1
SLC5A1
0.020 AlteredExpression disease BEFREE Increased gene expression levels of sodium-glucose cotransporter 1 (SGLT1) are associated with hypertrophic and ischemic cardiomyopathy. 30101852 2018
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.020 Biomarker disease BEFREE Effects of different doses of granulocyte colony-stimulating factor mobilization therapy on ischemic cardiomyopathy. 29651017 2018
Entrez Id: 406913
Gene Symbol: MIR126
MIR126
0.020 AlteredExpression disease BEFREE Methods and Results: miR-126-3p overexpression by lentiviral vector significantly increased migration and tube-like structures of EPCs from ICM patients. 29998929 2018