Prediabetes<sub>IEC</sub> was diagnosed by "HbA<sub>1c</sub> 42-46 mmol/mol and/or FPG 6.1-6.9 mmol/L", Prediabetes<sub>ADA</sub> by "HbA<sub>1c</sub> 39-46 mmol/mol and/or FPG 5.6-6.9 mmol/L", Prediabetes<sub>ADA-IEC</sub> for the condition met the ADA but not the IEC prediabetes definition, and the ADA-normal glucose regulation (NGR<sub>ADA</sub>) by both HbA<sub>1c</sub> and FPG lower than Prediabetes<sub>ADA</sub>.
Using ADA 2011 glycaemic categories, 33% (n = 693) of cohort 1 (prediabetes risk) had normal glucose regulation and 67% (n = 1419) had impaired glucose regulation.
Prediabetes defined using the ADA fasting glucose concentration cutoff (prevalence 4112 [38%] of 10 844 people; 95% CI 37·0-38·8) was the most sensitive for major clinical outcomes, whereas using the ADA HbA<sub>1c</sub> cutoff (2027 [19%] of 10 884 people; 18·0-19·4) and IEC HbA<sub>1c</sub> cutoff (970 [9%] of 10 844 people; 8·4-9·5), and the WHO fasting glucose concentration cutoff (1213 [11%] of 10 844 people; 10·6-11·8) were more specific.