Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2
Gene Symbol: A2M
A2M
0.040 Biomarker disease BEFREE Activated α2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses. 25720493 2015
Entrez Id: 2
Gene Symbol: A2M
A2M
0.040 AlteredExpression disease BEFREE We previously reported that advanced prostate cancer (PCa) patients with multiple distant bone metastases had markedly decreased serum α2M levels (<20 mg/dl) and no detection of α2M by immunoelectrophoresis (defined as α2M deficiency). 22576683 2012
Entrez Id: 2
Gene Symbol: A2M
A2M
0.040 AlteredExpression disease BEFREE We conclude that alpha(2)M*-induced increase in GRP78 synthesis is caused by transcriptional upregulation of TFII-I which binds to the GRP78 promoter and thus potentiates its cell survival and antipoptotic functions in 1-LN prostate cancer cells. 19097122 2009
Entrez Id: 2
Gene Symbol: A2M
A2M
0.040 Biomarker disease BEFREE Binding of α(2)M* to prostate cancer cell surface GRP78 upregulates mTORC1 and mTORC2 activation and promotes protein synthesis in the prostate cancer cells. 23272152 2013
Entrez Id: 8086
Gene Symbol: AAAS
AAAS
0.300 Biomarker disease CTD_human The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response. 24763052 2015
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.050 AlteredExpression disease BEFREE Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells. 19531574 2009
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.050 AlteredExpression disease BEFREE As expected, lycopene treatment (2.5-10 μM) significantly inhibited the proliferation of LNCaP cells during incubation for 96 h. Lycopene significantly increased the protein and mRNA expression of PPARγ and LXRα at 24 and 48 h, while the increased in the expression of ATP-binding cassette transporter 1 (ABCA1) was only evident 96 h. In addition, lycopene significantly decreased cellular total cholesterol levels and increased apoA1 protein expression at 96 h. Incubation of LNCaP cells with lycopene (10 μM) in the presence (20 μM) of a specific antagonist of PPARγ (GW9662) and LXRα (GGPP) restored the proliferation of LNCaP cells to the control levels and significantly suppressed protein expression of PPARγ and LXRα as well as increased cellular total cholesterol levels. 21334870 2012
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.050 AlteredExpression disease BEFREE Androgenic suppression of ATP-binding cassette transporter A1 expression in LNCaP human prostate cancer cells. 15520169 2004
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.050 Biomarker disease BEFREE These findings indicate that tumor-derived MT1-MMP enhances tumor cell migration through initiation of an autocrine loop requiring ectodomain shedding of membrane-bound RANKL in prostate cancer cells, and that Src is a key downstream mediator of RANKL-induced migration of prostate cancer cells. 20551048 2010
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.050 AlteredExpression disease BEFREE In human prostate biopsy samples, ABCA1 mRNA expression was ∼2-fold higher in the androgen deprivation therapy group than in subjects with benign prostatic hyperplasia or pretreatment prostate cancer groups. 20671065 2011
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.020 GeneticVariation disease BEFREE To determine if the C421A single nucleotide polymorphism (SNP) in the ATP-binding cassette transporter ABCG2 increases prostate cancer risk or affects survival. 18710444 2008
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.020 Biomarker disease BEFREE The role of ATP-binding cassette transporter genes in the progression of prostate cancer. 26708806 2016
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 PosttranslationalModification disease BEFREE Promoter methylation of ABCB1 predominantly occurred in PCa and was rarely detected in NPT (p < 0.001). 26459268 2016
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE Several combination therapies and small P-glycoprotein inhibitors have been proposed to improve the therapeutic potential of docetaxel in prostate cancer. 24853766 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE The frequency of positive methylation-specific PCR bands for APC, GSTP1, and MDR1 genes in prostate cancer samples was 64.1%, 54.0%, and 55.3%, respectively. 16166436 2005
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 PosttranslationalModification disease BEFREE CpG hypermethylation of MDR1 gene contributes to the pathogenesis and progression of human prostate cancer. 15342374 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE Role of the MDR-1-encoded multiple drug resistance phenotype in prostate cancer cell lines. 8105110 1993
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE Phosphatidylinositol 3'-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells. 15548710 2005
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE Receiver operator characteristic curve analyses suggested that CpG island hypermethylation changes at GSTP1, APC, RASSF1a, PTGS2, and MDR1 in various combinations can distinguish primary prostate cancer from benign prostate tissues with sensitivities of 97.3-100% and specificities of 92-100%. 15026333 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE Previously, we described that MDR phenotype in PCa could be related with high basal and drug-induced expression of MDR proteins P-Glycoprotein (P-Gp), MRP1, and LRP. 21480311 2011
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE Androgen responsiveness may be modulated by P-gp in prostate cancer cells. 14991868 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells. 12414639 2002
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE EGFR mediates docetaxel resistance in human castration-resistant prostate cancer through the Akt-dependent expression of ABCB1 (MDR1). 24888374 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE Epigenetic regulation of MDR1 gene through post-translational histone modifications in prostate cancer. 24344919 2014
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE YB-1 is upregulated during prostate cancer tumor progression and increases P-glycoprotein activity. 15042610 2004