Gene: TMPRSS2 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 Biomarker disease BEFREE <i>TMPRSS2-ERG</i> Controls Luminal Epithelial Lineage and Antiandrogen Sensitivity in <i>PTEN</i> and <i>TP53</i>-Mutated Prostate Cancer. 29844131 2018
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 Biomarker disease BEFREE <i>TMPRSS2:ERG</i> status was assessed by IHC for presence of ERG on archival tumor specimens for 912 patients with prostate cancer, of whom 48% were ERG-positive.<b>Results:</b> In multivariable models, we found no association between regular use of aspirin and risk of <i>ERG</i>-positive prostate cancer (HR, 1.02; 95% confidence interval, 0.85-1.23), nor any association with duration or frequency of aspirin use. 30108097 2018
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 Biomarker disease BEFREE 10) gene fusion in a chronic myelogenous leukaemia cell line and the TMPRSS2-ERG gene fusion in a prostate cancer cell line and tissues. 19136943 2009
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 GeneticVariation disease BEFREE Prostate cancer genes associated with TMPRSS2-ERG gene fusion and prognostic of biochemical recurrence in multiple cohorts. 20068566 2010
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 GeneticVariation disease BEFREE Prostate cancer with large cribriform glands revealed rare TMPRSS2-ERG gene fusion. 20800881 2010
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 Biomarker disease BEFREE Prostate cancer (PCa) tumors harboring translocations of ETS family genes with the androgen responsive TMPRSS2 gene (ETS+ tumors) provide a robust biomarker for detecting PCa in approximately 70% of patients. 30367117 2019
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 Biomarker disease BEFREE TMPRSS2-ERG gene fusions have recently been reported to be present in a high proportion of human prostate cancers. 17043636 2007
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 Biomarker disease BEFREE TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort. 17237811 2007
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 AlteredExpression disease BEFREE TMPRSS2 localization and expression was evaluated in 415 cases of primary prostate cancer and 144 prostate cancer metastases by immunohistochemistry. 18338334 2008
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 GeneticVariation disease BEFREE TMPRSS2:ERG rearrangement was found in 60 of 125 (48%) prostate cancers. 18500259 2008
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 Biomarker disease BEFREE TMPRSS2:ERG fusions are promising prostate cancer biomarkers. 18948370 2008
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 Biomarker disease BEFREE TMPRSS2-ERG gene fusion was recently reported as the most common gene rearrangement in prostate cancer (PCA). 19029822 2009
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 Biomarker disease BEFREE TMPRSS2:ERG gene rearrangement appears to be an early event in prostate cancer and is not observed in benign or hyperplastic prostatic epithelium. 19642730 2009
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 GeneticVariation disease BEFREE TMPRSS2-ERG gene fusions occur in 50% of prostate cancers and result in the overexpression of a chimeric fusion transcript that encodes a truncated ERG product. 20651988 2010
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 GeneticVariation disease BEFREE TMPRSS2-ERG and other gene fusions involving ETS factors and genes with strong promoter elements are common in prostate cancer. 20713528 2010
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 Biomarker disease BEFREE TMPRSS2 gene fusions with ETS transcription factor family members ERG, ETV1, or ETV4 have been recently discovered as a common molecular event in prostate cancer. 20736744 2010
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 Biomarker disease BEFREE TMPRSS2:ERG had the greatest discriminatory value in predicting prostate cancer (AUC = 0.77 compared with 0.65 for PCA3 and 0.72 for serum PSA alone). 21600800 2013
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 Biomarker disease BEFREE TMPRSS2-ERG is the most common gene fusion in PCa, whereas activation of telomerase is a common feature of various malignancies. 22505341 2012
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 Biomarker disease BEFREE TMPRSS2-ERG had independent additional predictive value to PCA3 and the ERSPC risk calculator parameters for predicting PCa. 23201468 2014
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 GeneticVariation disease BEFREE TMPRSS2: ERG gene fusions are the most common types of gene fusions in prostate cancer. 23357671 2013
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 Biomarker disease BEFREE TMPRSS2-ERG is a recurrent rearrangement specific for prostate cancer, leading to the overexpression of a truncated ERG protein product that is amenable to immunohistochemical detection. 24266818 2013
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 Biomarker disease BEFREE TMPRSS2:ERG gene fusion predicts subsequent detection of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia. 24297949 2014
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 GeneticVariation disease BEFREE TMPRSS2:ERG fusions, in combination with deletion of the phosphatase and tensin homolog (PTEN) tumor suppressor, have been suggested to cooperatively drive tumor progression in prostate cancer. 24762546 2014
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 Biomarker disease BEFREE TMPRSS2:ETS fusions and clinicopathologic characteristics of prostate cancer patients from Eastern China. 24815454 2014
Entrez Id: 7113
Gene Symbol: TMPRSS2
TMPRSS2 		0.400 GeneticVariation disease BEFREE TMPRSS2-ERG fusions are strongly linked to young patient age in low-grade prostate cancer. 25015038 2014