Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 AlteredExpression disease BEFREE Meanwhile, the expression level of CCND1 was significantly upregulated in the PCa tissues and cell lines, which presented negative correlation with the expression of miR-487a-3p. 31309555 2020
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 AlteredExpression disease BEFREE Here, we identified microRNA-16-5p(miR-16-5p) is significantly upregulated in CaP LNCaP cells following IR and can enhance radiosensitivity through modulating Cyclin D1/E1-pRb-E2F1 pathway. 30536619 2019
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 AlteredExpression disease BEFREE Overall, these results suggest that miR-501-3p restricts prostate cancer cell growth by targeting CREPT to inhibit the expression of cyclin D1. 30621914 2019
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 AlteredExpression disease BEFREE As a result, the CCND1-RNASEL-CDKN1A-TP73-MDM2-UBE2I axis was identified as a bottleneck in the miRNA-mediated gene expression regulatory network of PCa according to network topological analysis. 29467540 2018
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 Biomarker disease BEFREE Long noncoding RNA LOXL1-AS1 regulates prostate cancer cell proliferation and cell cycle progression through miR-541-3p and CCND1. 30278884 2018
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 Biomarker disease BEFREE In conclusion, results present that SNHG7 regulates the cycle progression and acts as an oncogenic gene in the prostate cancer tumorigenesis via miR-503/Cyclin D1 pathway, revealing the vital role of lncRNA/miRNA/mRNA axis in prostate cancer carcinogenesis. 29571017 2018
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 AlteredExpression disease BEFREE Here, we demonstrate that RCN1 is overexpressed in clinical prostate cancer (PCa) samples, associated with cyclin B, not cyclin D1 expression, compared to that of benign tissues in a Chinese Han population. 29453900 2018
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 AlteredExpression disease BEFREE Expression of miR-124, STAT3, p-STAT3, Bcl-2 and Cyclin D1 was compared between normal human prostate epithelial cell RWPE-1 and prostate cancer cell DU145. 28617558 2017
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 AlteredExpression disease BEFREE Enforced expression of microRNA-590-3p led to repression of inositol polyphosphate 4-phosphatase type II messenger RNA and protein expression, as well as upregulation of p-Akt, p-FoxO3a, and cyclin D1 and downregulation of p21 expression in prostate cancer cell lines. 28345464 2017
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 Biomarker disease BEFREE Overexpression Numb had anti-cancer effects to prostatic cancer in vitro and vivo experiments, the mechanism might be P53/Cyclin D1 and Rac1/MMP-2/-9 signaling pathway. 28531799 2017
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 Biomarker disease BEFREE Using data from The Cancer Genome Atlas, we found that Slug expression positively correlated with that of c-Jun and cyclin D1 in human prostate cancers. 27385093 2016
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 Biomarker disease BEFREE Collectively, our findings suggest that the hormone-mediated recruitment of cyclin D1 to sites of DDR may facilitate the resistance of prostate cancer cells to DNA damage therapies and highlight the need to explore other therapeutic approaches in prostate cancer to prevent or overcome drug resistance. 26582866 2016
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 AlteredExpression disease BEFREE The levels of β-catenin and cyclin D1 in clinical PCa specimens were positively associated with Pin1 expression. 26497355 2016
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 GeneticVariation disease BEFREE Numerous epidemiological studies have evaluated the association between the CCND1 A870G polymorphism and the risk of prostate cancer (PCa). 25888980 2015
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 Biomarker disease BEFREE Here, our aim was to determine if miR-193b targets cyclin D1 in prostate cancer. 26129688 2015
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 AlteredExpression disease BEFREE SGK3 is an androgen-inducible kinase promoting prostate cancer cell proliferation through activation of p70 S6 kinase and up-regulation of cyclin D1. 24739041 2014
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 AlteredExpression disease BEFREE Finally, we demonstrated that rottlerin was able to suppress the expression of cyclin D1 and survivin, two targets of both Wnt/β-catenin and mTORC1 signaling, in prostate and breast cancer cells, and displayed remarkable anticancer activity with IC(50) values between 0.7 and 1.7 μM for prostate cancer PC-3 and DU145 cells and breast cancer MDA-MB-231 and T-47D cells. 24607787 2014
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 GeneticVariation disease BEFREE We tested whether genetic variations within the CCND1 gene are related to clinical outcomes in prostate cancer patients receiving radical prostatectomy. 23354566 2013
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 AlteredExpression disease BEFREE These findings suggest that CCND1 expression is possibly regulated by estrogens via ERβ and that this signaling pathway may influence prostate cancer development. 23060014 2013
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 AlteredExpression disease BEFREE Concomitantly, BBP treatment decreased the protein levels of phosphorylated retinoblastoma, cyclin D1 and E, cyclin-dependent kinase (CDK) 4 and 2, and pre-replication complex (CDC6 and MCM7) in LNCaP and PC-3 cells, whereas CDK inhibitor p27 was elevated in these cell lines. 22067725 2012
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 AlteredExpression disease BEFREE In the present study, we investigated the diagnostic value of 3 different genes associated with CaP carcinogenesis, encoding for cell cycle (MDM2, CCND1) and apoptotic (Fas) genes that are differentially expressed in CaP. 20822933 2012
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 Biomarker disease BEFREE Prostate cancer was used as a paradigm because this tumor type is reliant at all stages of the disease on androgen receptor (AR) signaling, and cyclin D1 has been shown to negatively modulate AR-dependent expression of prostate-specific antigen (KLK3/PSA). 21212260 2011
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 Biomarker disease BEFREE Therefore, deregulation of CCND1 may be a major cause of cisplatin resistance in testicular germ cell tumors and may also be implicated in ovarian and prostate cancers. 20395447 2010
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 Biomarker disease BEFREE Our results identify Sam68 as the first splicing factor to affect CCND1 alternative splicing in prostate cancer cells, and suggest that increased levels of Sam68 may stimulate cyclin D1b expression in human prostate cancers. 20028857 2010
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.600 AlteredExpression disease BEFREE Mining of publicly available human prostate cancer oligoarray datasets revealed that the expression of numerous genes (e.g., CCND1, CD44) under the control of beta-catenin transcription is down-regulated. 20454608 2010