Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE A significant association was found between CDH1 -160C/A (rs16260) and Exo1 (rs1047840, K589E) polymorphisms and prostate cancer risk. 30880589 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 AlteredExpression disease BEFREE Herein, we evaluated the E-cadherin protein and gene expression in canine PC compared to normal tissues. 31850082 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 AlteredExpression disease BEFREE Immunohistochemistry was used to detect the SARI and E-cadherin protein expression in the prostate cancer and benign prostatic hyperplasia specimens, and their correlation was established. 31276688 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 Biomarker disease BEFREE A total of seven hub genes, including phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS), cadherin 1 (CDH1), SRC proto‑oncogene, non‑receptor tyrosine kinase, twist family bHLH transcription factor 1 (TWIST1), ZW10 interacting kinetochore protein (ZWINT), PCNA clamp associated factor (KIAA0101) and androgen receptor, among which, five (PAICS, CDH1, TWIST1, ZWINT and KIAA0101) were significantly upregulated and negatively correlated with miR‑1, were identified as key miR‑1 target genes in PCa. 30365107 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 Biomarker disease BEFREE CLCA2 promoted PCa cell adhesion inhibiting epithelial-mesenchymal transition (EMT) and activating CTNNB1 together with epithelial marker (CDH1) induction, and mesenchymal markers (SNAI2 and TWIST1) repression. 29536528 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 Biomarker disease CTD_human Several of the affected genes were known to be associated with aggressive prostate cancer such as loss of PTEN, CDH1, BCAR1 and gain of MYC. 29295717 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 Biomarker disease CTD_human The long tail of oncogenic drivers in prostate cancer. 29610475 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 Biomarker disease BEFREE Furthermore, CNV in miR-15a, CDH1 and ZFHX3 were associated with presence of incidental prostate cancer (<i>p</i> = 0.023, 0.003, 0.025, respectively). 28915599 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 PosttranslationalModification disease BEFREE DNA methylation level of the E-Cadherin gene could be an important predictive index for malignancy of prostate cancer. 27420993 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE We aim to systematically evaluate the potential of promoter methylation and polymorphism in E-cadherin gene to confer a risk to prostate cancer through meta-analysis. 25056535 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 AlteredExpression disease BEFREE Consequently, knockdown of SATB1 in highly aggressive human prostate cancer PC-3M cells inhibited invasiveness and tumor growth in vivo along with increase in E-cadherin protein expression. 23308245 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 AlteredExpression disease BEFREE We have shown previously that cancer prevention by cruciferous vegetable constituent phenethyl isothiocyanate (PEITC) in a transgenic mouse model of prostate cancer is associated with induction of E-cadherin protein expression. 23682784 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 Biomarker disease CTD_human Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice. 22581815 2012
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 PosttranslationalModification disease BEFREE Several genes including CDH1 previously reported as methylation markers in PCa were not confirmed in our study. 21694441 2011
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE The E-cadherin (CDH1)--160 C/A polymorphism and prostate cancer risk: a meta-analysis. 18781193 2009
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE The presence of the A allele of the -160C/A polymorphism in the E-cadherin gene may be a risk factor for prostate cancer in the Japanese population. 17656222 2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE E-cadherin promoter polymorphisms are not associated with the aggressiveness of prostate cancer in Caucasian patients. 17138130 2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 Biomarker disease BEFREE Inherited variation in RNASEL, MSR1 and E-cadherin genes do not seem to contribute to prostate cancer development in Poland. 17627168 2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 Biomarker disease CTD_human The E-cadherin -160 C/A polymorphism and prostate cancer risk in white and black American men. 16813949 2006
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 Biomarker disease BEFREE The E-cadherin (CDH1) gene has been implicated in prostate cancer (PCA) risk, however, the exact mechanism is unknown. 16372334 2006
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE The distribution of the CDH-1 gene CC genotype in prostate cancer patients (51.0%) was higher than in the controls (10.5%). 16327305 2005
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Seven SNPs, including the promoter SNP rs16260, that captured over 96% of CDH1 haplotype variation were selected as haplotype tagging SNPs and analyzed for associated PC risk. 16189707 2005
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE We explored the association between E-cadherin gene polymorphism and the risk of prostate cancer in a Japanese population. 15741307 2005
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 Biomarker disease BEFREE We found that CpG islands at GSTP1, APC, RASSF1a, PTGS2, and MDR1 were hypermethylated in >85% of prostate cancers and cancer cell lines but not in normal prostate cells and tissues; CpG islands at EDNRB, ESR1, CDKN2a, and hMLH1 exhibited low to moderate rates of hypermethylation in prostate cancer tissues and cancer cell lines but were entirely unmethylated in normal tissues; and CpG islands at DAPK1, TIMP3, MGMT, CDKN2b, p14/ARF, and CDH1 were not abnormally hypermethylated in prostate cancers. 15026333 2004
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Our data indicate that the -160 single nucleotide polymorphism in CDH1 is a low-penetrant prostate cancer susceptibility gene that might explain a proportion of familial and notably hereditary prostate cancer. 14961571 2004