Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 GeneticVariation disease UNIPROT FGFR4 Gly388Arg polymorphism contributes to prostate cancer development and progression: a meta-analysis of 2618 cases and 2305 controls. 21349172 2011
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 GeneticVariation disease UNIPROT Gly388Arg polymorphism in FGFR4 gene has been reported to be involved in prostate cancer incidence and aggressiveness in several studies. 21349172 2011
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 GeneticVariation disease UNIPROT This meta-analysis showed the evidence that FGFR4 Gly388Arg polymorphism was associated with an increased risk of prostate cancer development and progression, suggesting that FGFR4 Gly388Arg polymorphism could be a marker for prostate cancer development and progression. 21349172 2011
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 GeneticVariation disease UNIPROT Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation. 20876804 2010
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 GeneticVariation disease UNIPROT In patients bearing the FGFR-4 Gly(388) variant, expression of Huntingtin-interacting protein 1 (HIP1), which occurs in more than half of human prostate cancers, also results in FGFR-4 stabilization. 18670643 2008
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 GeneticVariation disease UNIPROT Our results indicate that the FGFR4 Arg allele of the Gly388Arg polymorphism and the G allele of the rs2011077 polymorphism have a significant impact on the development of prostate cancer and BPH, and the progression of prostate cancer in a Japanese population. 18756523 2008
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 GeneticVariation disease UNIPROT Polymorphisms of fibroblast growth factor receptor 4 have association with the development of prostate cancer and benign prostatic hyperplasia and the progression of prostate cancer in a Japanese population. 18756523 2008
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 GeneticVariation disease UNIPROT We investigated the association between the Gly388Arg polymorphism or the G or A polymorphism at intron 11 (rs2011077) of FGFR4, which was located 1,213 base pairs apart from the Gly388Arg polymorphism, and the risk of prostate cancer or benign prostate hyperplasia (BPH), and the prostate cancer disease status in Japanese men. 18756523 2008
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 GeneticVariation disease UNIPROT Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression. 18670643 2008
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 GeneticVariation disease UNIPROT A common polymorphism of FGFR-4 in which arginine (Arg(388)) replaces glycine (Gly(388)) at amino acid 388 is associated with progression in human prostate cancer. 18670643 2008
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 GeneticVariation disease UNIPROT Genotypes of Gly388Arg and rs2011077 polymorphisms of FGFR4 were determined in 492 patients with prostate cancer, 165 patients with BPH and 179 male controls. 18756523 2008
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 GeneticVariation disease UNIPROT Fibroblast growth factor receptor 4 (FGFR-4) is expressed at significant levels in almost all human prostate cancers, and expression of its ligands is ubiquitous. 18670643 2008
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 GeneticVariation disease UNIPROT We show that the FGFR-4 Arg(388) polymorphism, which is present in most prostate cancer patients, results in increased receptor stability and sustained receptor activation. 18670643 2008
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 GeneticVariation disease UNIPROT Our findings indicate that increased receptor stability and sustained FGFR-4 signaling occur in most human prostate cancers due to either the presence of a common genetic polymorphism or the expression of a protein that stabilizes FGFR-4. 18670643 2008
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 Biomarker disease CTD_human Homozygosity for the FGFR-4 Arg388 allele is strongly associated with the occurrence of prostate cancer in white men. 15448004 2005
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 Biomarker disease CTD_human The FGFR-4 Arg388 allele is associated with both an increased incidence and clinical aggressiveness of prostate cancer and results in changes in cellular motility and invasiveness in immortalized prostate epithelial cells consistent with the promotion of metastasis. 15448004 2005
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 Biomarker disease CTD_human The fibroblast growth factor receptor-4 Arg388 allele is associated with prostate cancer initiation and progression. 15448004 2005
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 Biomarker disease CTD_human We therefore sought to determine whether the FGFR-4 Arg388 allele was associated with prostate cancer incidence and/or the occurrence of aggressive disease. 15448004 2005
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.600 Biomarker disease CTD_human Increased expression of fibroblast growth factors that can activate the fibroblast growth factor receptor-4 (FGFR-4) occurs in a substantial fraction of human prostate cancers in vivo. 15448004 2005