Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.300 Biomarker phenotype BEFREE Male C57BL/6 mice with or without endotoxaemia were exposed to MV (10 mL/kg) for 8 hours after administrating either 100 mg/kg of EP or 100 mg/kg of anti-HMGB1 antibody. 31339670 2019
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.300 Biomarker phenotype BEFREE Here we discovered that hepatocyte-released high mobility group box 1 (HMGB1) was required for caspase-11-dependent pyroptosis and lethality in endotoxemia and bacterial sepsis. 30314759 2018
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.300 Biomarker phenotype BEFREE Ethyl pyruvate (EP) was previously shown to inhibit HMGB1 release and promote survival during endotoxemia and experimental sepsis. 30134814 2018
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.300 Biomarker phenotype BEFREE Our in vivo and in vitro studies show dioscin protects hippocampus from endotoxemia induced cascade neuro-inflammation through neurotransmitter 5-HT and HMGB-1/TLR4 signaling pathway, which accounts for the dioscin therapeutic effect in behavioral tests. 28059131 2017
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.300 Biomarker phenotype BEFREE A Dalbergia odorifera extract improves the survival of endotoxemia model mice by inhibiting HMGB1 release. 28403838 2017
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.300 Biomarker phenotype BEFREE Pre-clinically, administration of neutralising ovine anti-HMGB1 polyclonal antibodies improved survival in murine endotoxaemia and caecal ligation and puncture-induced sepsis models, and altered early cytokine profiles to one which corresponded to patterns observed in the surviving patient cohort. 28724977 2017
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.300 AlteredExpression phenotype BEFREE These observations suggest that identification of agents, including those in the herb <i>C. longa</i>, that can inhibit HMGB1 production and/or activity may aid the treatment of endotoxemia. 28929026 2017
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.300 Biomarker phenotype BEFREE Highlights of this study include: human SAA is possibly only expressed in a subset of septic patients; SAA induces HMGB1 release via TLR4 and RAGE receptors; SAA supplementation worsens the outcome of lethal endotoxemia; whereas SAA-neutralizing antibodies confer protection against lethal endotoxemia and sepsis. 26052716 2015
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.300 Biomarker phenotype BEFREE High mobility group box-1 (HMGB1) protein is involved in the process of endotoxemia. 20943459 2010
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.300 AlteredExpression phenotype BEFREE In the present study, we wanted to determine whether tissue and circulating levels of HMGB1 are increased further in the absence of HO-1 during endotoxemia, and whether this increase may contribute to the pathobiology of endotoxemia. 19097991 2009
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.300 Biomarker phenotype RGD High mobility group box 1 induces a negative inotropic effect on the left ventricle in an isolated rat heart model of septic shock: a pilot study. 18503231 2008
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.300 Biomarker phenotype BEFREE Passive immunization with anti-HMGB1 antibodies confers significant protection against lethal endotoxaemia, sepsis, arthritis and lipopolysaccharide-induced acute lung injury, even when antibody administration is delayed until after the early TNF responses have resolved. 14871456 2004