Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 203228
Gene Symbol: C9orf72
C9orf72
0.310 Biomarker disease CTD_human Genetic variation associated with the occurrence and progression of neurological disorders. 27713094 2017
Entrez Id: 8878
Gene Symbol: SQSTM1
SQSTM1
0.310 GeneticVariation disease BEFREE SQSTM1 mutations in French patients with frontotemporal dementia or frontotemporal dementia with amyotrophic lateral sclerosis. 24042580 2013
Entrez Id: 203228
Gene Symbol: C9orf72
C9orf72
0.310 GeneticVariation disease BEFREE The study examined whether there are clinical differences between FTD-ALS patients with and without expansions in C9orf72. 23421625 2013
Entrez Id: 8878
Gene Symbol: SQSTM1
SQSTM1
0.310 Biomarker disease CTD_human Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism. 19765191 2009
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.300 Biomarker disease CTD_human Resveratrol treatment reduces the vulnerability of SH-SY5Y cells and cortical neurons overexpressing SOD1-G93A to Thimerosal toxicity through SIRT1/DREAM/PDYN pathway. 30503815 2019
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.300 Biomarker disease CTD_human ALS mutations of FUS suppress protein translation and disrupt the regulation of nonsense-mediated decay. 30455313 2018
Entrez Id: 5444
Gene Symbol: PON1
PON1
0.300 Biomarker disease CTD_human Organophosphate neurotoxicity to the voluntary motor system on the trail of environment-caused amyotrophic lateral sclerosis: the known, the misknown, and the unknown. 28070599 2017
Entrez Id: 6311
Gene Symbol: ATXN2
ATXN2
0.300 Biomarker disease CTD_human Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis. 27377857 2017
Entrez Id: 755
Gene Symbol: CFAP410
CFAP410
0.300 Biomarker disease CTD_human Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. 27455348 2016
Entrez Id: 23256
Gene Symbol: SCFD1
SCFD1
0.300 Biomarker disease CTD_human Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. 27455348 2016
Entrez Id: 4750
Gene Symbol: NEK1
NEK1
0.300 Biomarker disease CTD_human NEK1 mutations in familial amyotrophic lateral sclerosis. 26945885 2016
Entrez Id: 4750
Gene Symbol: NEK1
NEK1
0.300 Biomarker disease CTD_human NEK1 variants confer susceptibility to amyotrophic lateral sclerosis. 27455347 2016
Entrez Id: 4336
Gene Symbol: MOBP
MOBP
0.300 Biomarker disease CTD_human Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. 27455348 2016
Entrez Id: 10280
Gene Symbol: SIGMAR1
SIGMAR1
0.300 Biomarker disease CTD_human Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G⁹³A ALS mice: overlapping effects or limited therapeutic opportunity? 24885036 2014
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.300 Biomarker disease CTD_human Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G⁹³A ALS mice: overlapping effects or limited therapeutic opportunity? 24885036 2014
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.300 Biomarker disease CTD_human A high-content screen identifies novel compounds that inhibit stress-induced TDP-43 cellular aggregation and associated cytotoxicity. 24019256 2014
Entrez Id: 10133
Gene Symbol: OPTN
OPTN
0.300 Biomarker disease CTD_human Optineurin associates with the podocyte Golgi complex to maintain its structure. 25096716 2014
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.300 Biomarker disease CTD_human Identification of a misfolded region in superoxide dismutase 1 that is exposed in amyotrophic lateral sclerosis. 25164820 2014
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.300 Biomarker disease CTD_human Motor neuron dysfunction in a mouse model of ALS: gender-dependent effect of P2X7 antagonism. 23583883 2013
Entrez Id: 27242
Gene Symbol: TNFRSF21
TNFRSF21
0.300 Biomarker disease CTD_human Death receptor 6 (DR6) antagonist antibody is neuroprotective in the mouse SOD1G93A model of amyotrophic lateral sclerosis. 24113175 2013
Entrez Id: 57172
Gene Symbol: CAMK1G
CAMK1G
0.300 Biomarker disease CTD_human Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis. 23624525 2013
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.300 Biomarker disease CTD_human Reducing TDP-43 aggregation does not prevent its cytotoxicity. 24252504 2013
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.300 Biomarker disease CTD_human Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. 23104007 2012
Entrez Id: 51163
Gene Symbol: DBR1
DBR1
0.300 Therapeutic disease CTD_human Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. 23104007 2012
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
0.300 Biomarker disease CTD_human Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes. 22879928 2012