×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
Interestingly, DBS for PD can cause dystonia such as blepharospasm and bilateral pallidal DBS for dystonia can result in features of parkinsonism.
31078682
2019
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
A dramatic and long-lasting response to DBS is characteristic of DYT-KMT2B dystonia .
31216378
2019
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
DBS has been trialed to treat related movement disorders, particularly dystonia .
30633810
2019
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
Pallidal deep-brain stimulation of the internal globus pallidus (GPi-DBS ) is an effective treatment for dystonia .
30623266
2019
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
To objectively investigate the impact of GPi-DBS on patients with dystonia on speech fluency, intelligibility, and key aspects of hyperkinetic and hypokinetic dysarthria.
29576500
2019
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
Peak low frequency IMC functioned as biomarker for GPi-DBS efficacy, and partly correlated with dystonia severity.
31207566
2019
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
We aimed to assess whether the thalamic ventral intermediate nucleus (Vim) might be an alternative DBS target in dystonia -choreoathetosis.
30718219
2019
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
All these results support the multilevel impact of effective DBS on the motor networks in dystonia and suggest potential biomarkers of responsiveness to this treatment.
30464181
2018
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
Fifty-four subjects with dystonia and DBS for more than 5 years were contacted via social media and were offered to complete a quality-of-life survey comparing current-day life and life prior to DBS .
30153389
2018
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
We describe lessons learnt from available dystonia studies and discuss/propose ways to measure DBS and other dystonia -related intervention outcomes.
27707656
2017
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
Our results showed that bilateral GPi DBS in craniocervical dystonia is effective and safe.
29246604
2017
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
We here investigated causes of insufficient response to GPi-DBS in isolated dystonia in a cross-sectional study.
28690015
2017
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
DBS effects on dystonia severity were variable but overall marginally effective, with a mean improvement of 7.9% (p = 0.39) at 1-year follow-up and 16.7% (p = 0.46) at last follow-up (mean 47.3 ± 19.9 months after surgery).
27743838
2017
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
To assess safety and tolerability of square biphasic DBS in dystonia patients.
28195407
2017
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
GPi DBS is an effective and safe treatment in most patients with dystonia .
28972096
2017
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
Pallidal DBS for dystonia in the age of personalized medicine.
28964627
2017
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
GPi-DBS should be considered to ameliorate the invalidating dystonia in these patients.
27862284
2017
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
As the course of disease duration as well as the age at operation seem to correlate with DBS outcome in patients with dystonia , DBS at an early stage of development might be beneficial for some of these patients.
27289260
2017
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
Clinically, no generalization of dystonia was observed after onset and DBS lead to an excellent motor outcome in two cases.
26725140
2016
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
There was a significant improvement of dystonia with GPi-DBS (69 % improvement in Burke-Fahn-Marsden score, p < 0.0001).
24178706
2014
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
GeneticVariation
group
BEFREE
Some of the rarer types of dystonia that have also been treated with DBS are also described.
20083014
2009
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
The present study confirms the effectiveness of pallidal DBS in a new family with hereditary primary segmental and generalized dystonia .
19890997
2009
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
0.100
Biomarker
group
BEFREE
This study shows the benefits of pallidal DBS for the dystonia of PKAN patients.
15852393
2005