As compared with later-onset disease, IO-IBD were more likely to present with bloody diarrhea (100% <i>vs</i> 55%, <i>P</i> = 0.039) but were similar in terms of an associated autoimmune liver disease (0% <i>vs</i> 19%, <i>P</i> = 0.31), requiring biologics therapy (50% <i>vs</i> 36%, <i>P</i> = 0.40), surgery (50% <i>vs</i> 29%, <i>P</i> = 0.27), or achieving remission (50% <i>vs</i> 64%, <i>P</i> = 0.40).