Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1737
Gene Symbol: DLAT
DLAT
0.030 Biomarker disease BEFREE PBC is a prototypical autoimmune liver disease characterized by portal lymphoplasmacyte infiltration. 28834158 2018
Entrez Id: 1737
Gene Symbol: DLAT
DLAT
0.030 Biomarker disease BEFREE Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury, cholestasis and progressive fibrosis can culminate over time in an end-stage biliary cirrhosis. 29593060 2018
Entrez Id: 1737
Gene Symbol: DLAT
DLAT
0.030 Biomarker disease BEFREE Autoimmune liver disease (AILD) encompasses 3 main distinct clinical diseases: autoimmune hepatitis, primary biliary cholangitis (formally known as cirrhosis, PBC) and primary sclerosing cholangitis (PSC). 27170385 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.010 Biomarker disease BEFREE Elevated CRP is an accurate marker for diagnosing bacterial infection in autoimmune liver disease-associated ACLF patients. 29623264 2018
Entrez Id: 29108
Gene Symbol: PYCARD
PYCARD
0.010 Biomarker disease BEFREE There is limited literature on the spectrum of pediatric autoimmune liver disease (AILD, encompassing both autoimmune hepatitis/AIH and autoimmune sclerosing cholangitis [ASC]) in Asian populations and its diagnostic scores similarly require further validation. 29901555 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.010 GeneticVariation disease BEFREE Our meta-analysis strongly suggests that the IL10 rs1800896, rs1800871, and rs1800872 polymorphisms are not associated with the risk of autoimmune liver disease. 29694797 2018
Entrez Id: 412
Gene Symbol: STS
STS
0.010 Biomarker disease BEFREE There is limited literature on the spectrum of pediatric autoimmune liver disease (AILD, encompassing both autoimmune hepatitis/AIH and autoimmune sclerosing cholangitis [ASC]) in Asian populations and its diagnostic scores similarly require further validation. 29901555 2018
Entrez Id: 9448
Gene Symbol: MAP4K4
MAP4K4
0.010 GeneticVariation disease BEFREE We found that global or thymus-specific ablation of the NIK gene results in fatal autoimmune liver disease in mice. 28267623 2017
Entrez Id: 912
Gene Symbol: CD1D
CD1D
0.010 AlteredExpression disease BEFREE Lay summary: CD1d overexpression on T cells enhances crosstalk between type II NKT cells and T cells, resulting in their aberrant activation and leading to the development of chronic autoimmune liver disease. 28596110 2017
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
0.010 GeneticVariation disease BEFREE We found that global or thymus-specific ablation of the NIK gene results in fatal autoimmune liver disease in mice. 28267623 2017
Entrez Id: 27034
Gene Symbol: ACAD8
ACAD8
0.010 Biomarker disease BEFREE As compared with later-onset disease, IO-IBD were more likely to present with bloody diarrhea (100% <i>vs</i> 55%, <i>P</i> = 0.039) but were similar in terms of an associated autoimmune liver disease (0% <i>vs</i> 19%, <i>P</i> = 0.31), requiring biologics therapy (50% <i>vs</i> 36%, <i>P</i> = 0.40), surgery (50% <i>vs</i> 29%, <i>P</i> = 0.27), or achieving remission (50% <i>vs</i> 64%, <i>P</i> = 0.40). 28082818 2016
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.010 GeneticVariation disease BEFREE SNPs in the PTPN22 gene may therefore play key roles in the genetic resistance to autoimmune liver disease in the Japanese. 27406031 2016
Entrez Id: 953
Gene Symbol: ENTPD1
ENTPD1
0.010 Biomarker disease BEFREE As the proportion of CD39 lymphocytes is decreased in juvenile autoimmune liver disease (AILD), we have explored whether decreased CD39 expression is present on Th17 cells and whether this phenomenon is associated with heightened effector function and inflammation. 27210814 2016
Entrez Id: 115908
Gene Symbol: CTHRC1
CTHRC1
0.010 AlteredExpression disease BEFREE Treatment of cholestatic fibrosis by altering gene expression of Cthrc1: Implications for autoimmune and non-autoimmune liver disease. 26238209 2015
Entrez Id: 4282
Gene Symbol: MIF
MIF
0.010 Biomarker disease BEFREE The role of macrophage migration inhibitory factor in autoimmune liver disease. 23913513 2014
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
0.010 Biomarker disease BEFREE In the present study we used the CYP2D6 model to assess why tolerance breakdown and induction of autoimmune liver disease is more efficient if the triggering antigen is similar but not identical to the target autoantigen. 23200317 2013
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
0.010 GeneticVariation disease BEFREE We describe the association of the CTLA4 -318C>T variation with chronic HBV infection and cryptogenic cirrhosis but find no association of the +49G>A variation with autoimmune liver disease. 18049163 2007
Entrez Id: 174
Gene Symbol: AFP
AFP
0.010 Biomarker disease BEFREE Immunotherapy directed against alpha-fetoprotein results in autoimmune liver disease during liver regeneration in mice. 11606506 2001
Entrez Id: 1629
Gene Symbol: DBT
DBT
0.010 Biomarker disease BEFREE BCOADC-E2 subunit, a mitochondrial protein, has been known to be the autoantigen of primary biliary cirrhosis (PBC), a chronic autoimmune liver disease, as well as idiopathic dilated cardiomypathy (IDCM), a chronic autoimmune heart disease. 9873825 1998
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.010 GeneticVariation disease BEFREE In recent years there has been an increasing interest in the link between susceptibility to autoimmune liver disease and genes of the HLA system, although the role of the DPB1 locus in British patients has only been investigated in autoimmune hepatitis. 7705806 1995
Entrez Id: 8615
Gene Symbol: USO1
USO1
0.010 Biomarker disease BEFREE Other genes may contribute to susceptibility to autoimmune liver disease--for example the contribution of TAP genes, upstream promoter sequences and class III genes on chromosome 6 and the T-cell receptor genes and complement genes elsewhere in the human genome is currently unclear. 8020893 1994
Entrez Id: 2317
Gene Symbol: FLNB
FLNB
0.010 Biomarker disease BEFREE Other genes may contribute to susceptibility to autoimmune liver disease--for example the contribution of TAP genes, upstream promoter sequences and class III genes on chromosome 6 and the T-cell receptor genes and complement genes elsewhere in the human genome is currently unclear. 8020893 1994
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.010 Biomarker disease BEFREE Circulating intercellular adhesion molecule-1 (ICAM-1) in autoimmune liver disease and evidence for the production of ICAM-1 by cytokine-stimulated human hepatocytes. 7904546 1994
Entrez Id: 23541
Gene Symbol: SEC14L2
SEC14L2
0.010 Biomarker disease BEFREE Other genes may contribute to susceptibility to autoimmune liver disease--for example the contribution of TAP genes, upstream promoter sequences and class III genes on chromosome 6 and the T-cell receptor genes and complement genes elsewhere in the human genome is currently unclear. 8020893 1994
Entrez Id: 10482
Gene Symbol: NXF1
NXF1
0.010 Biomarker disease BEFREE Other genes may contribute to susceptibility to autoimmune liver disease--for example the contribution of TAP genes, upstream promoter sequences and class III genes on chromosome 6 and the T-cell receptor genes and complement genes elsewhere in the human genome is currently unclear. 8020893 1994