This study provides evidence of a significant association between the PEMTrs7946 A-allele and a risk of NAFLD, with the effect being more prominent in East-Asians, but not in non-Asians.
We investigated a large-scale analysis of the association between microsomal triglyceride transfer protein (MTTP) and phosphatidylethanolamine N-methyltransferase (PEMT) polymorphism in alcoholic and nonalcoholic fatty liver disease.
For the first time we report that a polymorphism of the human PEMT gene (V175M) is associated with diminished activity and may confer susceptibility to NAFLD.