Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.070 | Biomarker | disease | BEFREE | <b>Purpose:</b> The present study aimed to explore the effect of OA and UA on the expression of UGT1As in HepG2 cells and the regulatory mechanisms on UGT1A1 based on the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) signaling pathways. | 31611795 | 2019 | ||||
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0.070 | Biomarker | disease | BEFREE | CAR immunoreactivity was very low in normal and non-DCM hearts, whereas strong CAR signals occurred at the intercalated discs and sarcolemma in 5 of the 8 DCM hearts (62.5%); these strong signals colocalized with both integrins. | 11457744 | 2001 | ||||
|
0.070 | Biomarker | disease | BEFREE | CAR (Nr1i3), a liver nuclear receptor and xenobiotic sensor, induces drug, steroid and lipid metabolism and dysregulates genes linked to hepatocellular carcinogenesis, but its impact on the liver epigenome is poorly understood. | 31236583 | 2019 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Activation of the nuclear receptor and transcription factor CAR (Nr1i3) by its specific agonist ligand TCPOBOP (1, 4-bis[2-(3, 5-dichloropyridyloxy)]benzene) dysregulates hundreds of genes in mouse liver and is linked to male-biased hepatocarcinogenesis. | 29617930 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | The carCTL immune synapse lacked distinct LFA-1 adhesion rings and was less reliant on LFA to form stable conjugates with target cells. carCTL receptors associated with the synapse were found to be disrupted and formed a convoluted multifocal pattern of Lck microclusters. | 29440406 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | The nuclear receptor CAR (NR1I3) regulates hepatic drug and energy metabolism as well as cell fate. | 28265001 | 2017 | ||||
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0.070 | Biomarker | disease | BEFREE | Therefore, we hypothesized that genetic variations in xenobiotic transport and metabolism regulator genes PXR (NR1I2) and CAR (NR1I3) could determine a difference in MM susceptibility. | 23303387 | 2013 |