×
Entrez Id:
8200
Gene Symbol:
GDF5
GDF5
0.500
GeneticVariation
disease
GWASCAT
Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.
30374069
2018
×
Entrez Id:
8200
Gene Symbol:
GDF5
GDF5
0.500
GeneticVariation
disease
BEFREE
Interaction between GDF5 gene polymorphisms and environment factors increased the risk of knee osteoarthritis : a case-control study.
30777926
2019
×
Entrez Id:
8200
Gene Symbol:
GDF5
GDF5
0.500
GeneticVariation
disease
BEFREE
The growth differentiation factor 5 (GDF5 ) core promoter polymorphism is not associated with knee osteoarthritis in the Greek population.
17676627
2008
×
Entrez Id:
8200
Gene Symbol:
GDF5
GDF5
0.500
GeneticVariation
disease
LHGDN
A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility.
18299287
2008
×
Entrez Id:
8200
Gene Symbol:
GDF5
GDF5
0.500
GeneticVariation
disease
BEFREE
A genetic association study between growth differentiation factor 5 (GDF 5 ) polymorphism and knee osteoarthritis in Thai population.
21936909
2011
×
Entrez Id:
8200
Gene Symbol:
GDF5
GDF5
0.500
GeneticVariation
disease
BEFREE
Two thousand four hundred and sixty-two subjects aged 50 years and older were assessed for OA at the knee, were genotyped with two SNPs (GDF5 ; rs143383 and ADAM12; rs3740199 ).
22284607
2012
×
Entrez Id:
8200
Gene Symbol:
GDF5
GDF5
0.500
GeneticVariation
disease
BEFREE
These results strongly suggest that the C allele and CC genotype of the GDF5 gene are protective for knee OA susceptibility across different populations.
25467786
2014
×
Entrez Id:
8200
Gene Symbol:
GDF5
GDF5
0.500
GeneticVariation
disease
BEFREE
We observed demethylation of the GDF5 5'UTR in OA knee cartilage relative to both OA (p = 0.009) and non-OA (p = 0.001) hip cartilage, with the most significant demethylation observed at the highly conserved +37 CpG site located 4 bp upstream of rs143383 .
24861163
2014
×
Entrez Id:
8200
Gene Symbol:
GDF5
GDF5
0.500
GeneticVariation
disease
BEFREE
The meta-analysis results demonstrated that the +104T/C polymorphism in the 5'-UTR of GDF5 is associated with risk of knee osteoarthritis .
23151597
2013
×
Entrez Id:
8200
Gene Symbol:
GDF5
GDF5
0.500
GeneticVariation
disease
GWASCAT
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
30664745
2019
×
Entrez Id:
8200
Gene Symbol:
GDF5
GDF5
0.500
GeneticVariation
disease
BEFREE
This population-based study shows that GDF5 gene variants are associated with hand OA, knee OA and fracture risk in elderly women.
19029166
2009
×
Entrez Id:
8200
Gene Symbol:
GDF5
GDF5
0.500
GeneticVariation
disease
BEFREE
That has proven to be the case for the GDF5 polymorphism rs143383 , a risk factor for knee osteoarthritis and several other common conditions, including lumbar-disc degeneration and developmental dysplasia of the hip.
21542882
2011
×
Entrez Id:
8200
Gene Symbol:
GDF5
GDF5
0.500
GeneticVariation
disease
BEFREE
To discover if there is an association between the SNP rs143383 + 104T/C , in the GDF5 gene and the risk of developing KOA in individuals from northern Mexico.
30044130
2018
×
Entrez Id:
4052
Gene Symbol:
LTBP1
LTBP1
0.400
GeneticVariation
disease
GWASCAT
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
30664745
2019
×
Entrez Id:
55206
Gene Symbol:
SBNO1
SBNO1
0.400
GeneticVariation
disease
GWASCAT
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
30664745
2019
×
Entrez Id:
4052
Gene Symbol:
LTBP1
LTBP1
0.400
GeneticVariation
disease
GWASCAT
Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.
30374069
2018
×
Entrez Id:
55206
Gene Symbol:
SBNO1
SBNO1
0.400
GeneticVariation
disease
GWASCAT
Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.
30374069
2018
×
Entrez Id:
11060
Gene Symbol:
WWP2
WWP2
0.400
GeneticVariation
disease
GWASCAT
Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.
30374069
2018
×
Entrez Id:
7039
Gene Symbol:
TGFA
TGFA
0.320
GeneticVariation
disease
GWASCAT
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
30664745
2019
×
Entrez Id:
7039
Gene Symbol:
TGFA
TGFA
0.320
GeneticVariation
disease
BEFREE
Association of Common Variants in TGFA with Increased Risk of Knee Osteoarthritis Susceptibility.
28777012
2017
×
Entrez Id:
3552
Gene Symbol:
IL1A
IL1A
0.260
GeneticVariation
disease
BEFREE
IL1R1, encoding interleukin 1 receptor type 1, is located in the IL-1 gene cluster and is involved in the pathogenesis of hand, hip, and knee osteoarthritis (OA ) in different ethnicities.
27980229
2017
×
Entrez Id:
3552
Gene Symbol:
IL1A
IL1A
0.260
GeneticVariation
disease
BEFREE
Other IL-1 gene variations were tested for association with OA progression as a secondary objective.
23602982
2013
×
Entrez Id:
3552
Gene Symbol:
IL1A
IL1A
0.260
GeneticVariation
disease
BEFREE
Extended haplotypes and linkage disequilibrium in the IL1R1-IL1A -IL1B-IL1RN gene cluster: association with knee osteoarthritis .
15190266
2004
×
Entrez Id:
4314
Gene Symbol:
MMP3
MMP3
0.240
GeneticVariation
disease
BEFREE
Genotype distributions and allelic frequencies of MMP-3 -1612 5A/6A polymorphism were investigated in 200 participants (100 patients with knee osteoarthritis and 100 healthy controls).
22457004
2013
×
Entrez Id:
4312
Gene Symbol:
MMP1
MMP1
0.230
GeneticVariation
disease
BEFREE
These findings suggest that the -1,607 1G/2G polymorphism in the MMP-1 gene may contribute to susceptibility to knee osteoarthritis in the Turkish population.
18802702
2009