Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.090 Biomarker disease BEFREE Treatment with murine ICOSL/BAFF bispecific or combination therapy was more efficacious than single ICOSL or BAFF inhibitor in mouse NZB/NZW lupus model. 30789152 2019
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.090 Biomarker disease BEFREE The administration of belimumab, a monoclonal antibody specific for BAFF and approved for lupus therapy, could potentiate the efficacy of rituximab and enable longer periods of disease remission. 31848169 2019
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.090 AlteredExpression disease BEFREE The aim of the current study is to explore whether serum BAFF levels along with variants of the BAFF gene increase lupus related atherosclerotic risk. 29859654 2018
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.090 Biomarker disease BEFREE G-744 is efficacious, and superior to blocking BAFF and Syk, in ameliorating severe lupus nephritis in both spontaneous and IFNα-accelerated lupus in NZB/W_F1 mice in therapeutic regimens. 28405610 2017
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.090 Biomarker disease BEFREE The purpose of this study was to determine whether BAFF, a key pathogenic factor in systemic lupus erythematosus, also a dichotomous regulator for B-cell immune responses, has an effect on IL-35-producing regulatory B cells and their underlying mechanisms in lupus. 28844943 2017
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.090 AlteredExpression disease BEFREE Serum levels of BAFF and APRIL have shown inconsistent relationships with lupus disease activity. 27804111 2017
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.090 Biomarker disease BEFREE Thus, we have identified a novel role for BCMA to control excess BAFF production in murine lupus through restraining the accumulation of BAFF-producing neutrophils. 25010693 2014
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.090 Biomarker disease BEFREE BAFF is an important pathogenic factor in lupus mouse models and BAFF inhibition successfully delays disease onset in these mice, although the responsiveness to BAFF inhibition varies among different strains. 21333645 2011
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.090 AlteredExpression disease BEFREE Since excessive B cell-activating factor belonging to the TNF family (BAFF) expression correlates with human and murine lupus, and BAFF signals B cell survival through BAFF-R, it is believed that excessive BAFF-R signaling can subvert B cell tolerance and facilitate lupus development. 18200501 2008