| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | In vitro experiments showed that lupus CD4<sup>+</sup> T cells had more pronounced IRAK1 phosphorylation at threonine-209 upon IL-1β stimulation than did control cells. | 29611775 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | We determined the role of IL-1 in lupus skin injury by using gene deficient mice. | 28396236 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | Included in this rubric is the concept that activation of the inflammasome, a molecular complex that activates caspase-1 and in turn the cytokines IL-1β and IL-18, is important in lupus pathogenesis. | 24992143 | 2014 | ||||
|
0.070 | Biomarker | disease | BEFREE | Given that the expression of some of the p200-family proteins is differentially regulated by sex hormones and these proteins differentially regulate cytosolic DNA-induced production of type I IFN and proinflammatory cytokines (IL-1β and IL-18), the major known contributors of SLE-associated inflammation, we discuss the recent advancements in our understanding of the role of p200-family proteins in lupus susceptibility modification. | 22841963 | 2012 | ||||
|
0.070 | Biomarker | disease | BEFREE | IL-1β promotes significant improvement in the functional capacity of lupus EPCs/CACs, therefore abrogating the deleterious effects of IFN-α. | 20805419 | 2010 | ||||
|
0.070 | Biomarker | disease | BEFREE | Gene expression and protein synthesis of MCP-1, TGF-beta1 and IL-1beta in MeT-5A cells were significantly increased after incubation with IgG from patients with active lupus when compared with IgG from the inactive lupus and control groups (P < 0.01). | 14623950 | 2004 | ||||
|
0.070 | Biomarker | disease | BEFREE | Administration of cDNA encoding soluble IFN-gamma receptor (IFN-gamma R)/IgG-Fc fusion proteins, soluble TNF-alpha receptors, or IL-1 receptor antagonist (IL-1ra), protects against either lupus, various forms of arthritis, autoimmune diabetes, or other autoimmune diseases. | 11727511 | 2001 |