Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.100 Biomarker disease BEFREE PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21. 31536480 2019
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.100 Biomarker disease BEFREE Altogether, our results indicate that β2-Glycoprotein I is able to elicit a local Interleukin-17/Interleukin-21 and Interferon-γ inflammation in lupus-antiphospholipid syndrome patients that might lead, if unabated, to plaque instability and subsequent arterial thrombosis, suggesting that the T helper 17/T helper 1 pathway may represent a novel target for the prevention and treatment of the disease. 30872365 2019
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.100 GeneticVariation disease BEFREE Enhanced ABC formation in SWEF-deficient mice was controlled by the cytokine IL-21 and IRF5, whose variants are strongly associated with lupus. 29483597 2018
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.100 Biomarker disease BEFREE Anti-IL-21 treatment also led to a reduction in GC B cells, CD138<sup>hi</sup> plasmablasts, IFN-γ-dependent IgG2c production, and autoantibodies, indicating that Tfh cell-derived IL-21 is critical for pathological B cell cues in lupus. 28219887 2017
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.100 Biomarker disease BEFREE T cells contribute to lupus pathogenesis by secreting pro-inflammatory cytokines such as IL-17, and by interacting with B cells and secreting helper factors such as IL-21 that promote production of IgG autoantibodies. 24508410 2014
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.100 Biomarker disease BEFREE Addition of IL-21 to lupus autologous mixed lymphocyte cultures induced significant IgG production, and treatment with IL-21R.Fc to block IL-21/IL-21R interaction reduced the proportion of plasma cells. 23137515 2013
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.100 Biomarker disease BEFREE We detected and confirmed gene-gene interactions between the HLA region and CTLA4, IRF5, and ITGAM and between PDCD1 and IL21 in patients with lupus. 21952918 2012
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.100 Biomarker disease BEFREE Our findings establish the genetic association between lupus and IL2/IL21 with a genome-wide level of significance. 21425124 2011
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.100 AlteredExpression disease BEFREE The expression of IL-21 receptor (IL-21R) is reduced in the B cells of patients with systemic lupus erythematosus (SLE), while serum IL-21 levels are increased both in lupus patients and in some murine lupus models. 19644854 2009
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.100 Biomarker disease BEFREE Our data show for the first time that IL-21 has a pathogenic role in the MRL-Fas(lpr) lupus model by impacting B cell function and regulating the production of pathogenic autoantibodies. 17339481 2007
Entrez Id: 59067
Gene Symbol: IL21
IL21
0.100 Biomarker disease BEFREE The mutation disrupts a repressor of ICOS, an essential co-stimulatory receptor for follicular T cells, and results in excessive production of the cytokine interleukin-21. sanroque mice fail to repress diabetes-causing T cells, and develop high titres of autoantibodies and a pattern of pathology consistent with lupus. 15917799 2005