Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.020 Biomarker disease BEFREE Transforming growth factor beta 1 is a novel susceptibility gene for adolescent idiopathic scoliosis. 23446766 2013
Entrez Id: 7069
Gene Symbol: THRSP
THRSP 		0.010 AlteredExpression disease BEFREE Spot14/Spot14R expression may be involved in MSC adipogenic differentiation in patients with adolescent idiopathic scoliosis. 27082501 2016
Entrez Id: 450095
Gene Symbol: PLF
PLF 		0.020 Biomarker disease BEFREE Pulmonary function tests correlated with thoracic volumes in adolescent idiopathic scoliosis. 27208463 2017
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.020 Biomarker disease BEFREE Leptin in adolescent idiopathic scoliosis - A meta-analysis. 31493992 2020
Entrez Id: 81848
Gene Symbol: SPRY4
SPRY4 		0.010 Biomarker disease BEFREE SPRY4 is responsible for pathogenesis of adolescent idiopathic scoliosis by contributing to osteogenic differentiation and melatonin response of bone marrow-derived mesenchymal stem cells. 31645544 2019
Entrez Id: 10660
Gene Symbol: LBX1
LBX1 		0.100 Biomarker disease BEFREE A case-control association study was performed to investigate the relationship between ladybird homeobox (LBX1) and adolescent idiopathic scoliosis (AIS) in northern Chinese Han population. 28187071 2017
Entrez Id: 2690
Gene Symbol: GHR
GHR 		0.020 GeneticVariation disease BEFREE A conclusion was made confirming the insufficiency of an association between adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes in Han Chinese. 19634821 2009
Entrez Id: 3479
Gene Symbol: IGF1
IGF1 		0.030 GeneticVariation disease BEFREE A conclusion was made confirming the insufficiency of an association between adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes in Han Chinese. 19634821 2009
Entrez Id: 54796
Gene Symbol: BNC2
BNC2 		0.120 GeneticVariation disease GWASCAT A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis. 26211971 2015
Entrez Id: 101928989
Gene Symbol: MIR4300HG
MIR4300HG 		0.110 GeneticVariation disease BEFREE A functional variant in MIR4300HG, the host gene of microRNA MIR4300 is associated with progression of adolescent idiopathic scoliosis. 29016859 2017
Entrez Id: 100422823
Gene Symbol: MIR4300
MIR4300 		0.010 Biomarker disease BEFREE A functional variant in MIR4300HG, the host gene of microRNA MIR4300 is associated with progression of adolescent idiopathic scoliosis. 29016859 2017
Entrez Id: 101928989
Gene Symbol: MIR4300HG
MIR4300HG 		0.110 GeneticVariation disease GWASCAT A functional variant in MIR4300HG, the host gene of microRNA MIR4300 is associated with progression of adolescent idiopathic scoliosis. 29016859 2017
Entrez Id: 3953
Gene Symbol: LEPR
LEPR 		0.010 GeneticVariation disease BEFREE A genetic association study of leptin receptor (LEPR) gene with adolescent idiopathic scoliosis (AIS) in the Chinese Han population. 26731704 2015
Entrez Id: 57211
Gene Symbol: ADGRG6
ADGRG6 		0.160 GeneticVariation disease BEFREE A genetic association study of GPR126 gene with adolescent idiopathic scoliosis (AIS) in the Chinese population. 28198779 2017
Entrez Id: 10660
Gene Symbol: LBX1
LBX1 		0.100 GeneticVariation disease BEFREE A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis. 22019779 2011
Entrez Id: 10660
Gene Symbol: LBX1
LBX1 		0.100 GeneticVariation disease BEFREE A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups. 24721834 2014
Entrez Id: 7077
Gene Symbol: TIMP2
TIMP2 		0.010 GeneticVariation disease BEFREE A promoter polymorphism of tissue inhibitor of metalloproteinase-2 gene is associated with severity of thoracic adolescent idiopathic scoliosis. 21228746 2012
Entrez Id: 28
Gene Symbol: ABO
ABO 		0.110 Biomarker disease BEFREE A recent large-scale genome-wide association study reported three novel loci in CDH13, ABO, and SOX6 genes associated with adolescent idiopathic scoliosis (AIS) in Japanese population. 30994600 2019
Entrez Id: 55553
Gene Symbol: SOX6
SOX6 		0.110 Biomarker disease BEFREE A recent large-scale genome-wide association study reported three novel loci in CDH13, ABO, and SOX6 genes associated with adolescent idiopathic scoliosis (AIS) in Japanese population. 30994600 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1 		0.070 GeneticVariation disease BEFREE A relook into the association of the estrogen receptor [alpha] gene (PvuII, XbaI) and adolescent idiopathic scoliosis: a study of 540 Chinese cases. 17023856 2006
Entrez Id: 84818
Gene Symbol: IL17RC
IL17RC 		0.010 GeneticVariation disease BEFREE A single-nucleotide polymorphism rs708567 in the IL-17RC gene is associated with a susceptibility to and the curve severity of adolescent idiopathic scoliosis in a Chinese Han population: a case-control study. 22999050 2012
Entrez Id: 4544
Gene Symbol: MTNR1B
MTNR1B 		0.040 AlteredExpression disease BEFREE Abnormal melatonin receptor 1B expression in osteoblasts from girls with adolescent idiopathic scoliosis. 21480980 2011
Entrez Id: 5307
Gene Symbol: PITX1
PITX1 		0.010 PosttranslationalModification disease BEFREE Abnormal PITX1 gene methylation in adolescent idiopathic scoliosis: a pilot study. 29743058 2018
Entrez Id: 5077
Gene Symbol: PAX3
PAX3 		0.110 AlteredExpression disease BEFREE Abnormal paravertebral muscles development is associated with abnormal expression of PAX3 in adolescent idiopathic scoliosis. 31832874 2020
Entrez Id: 54796
Gene Symbol: BNC2
BNC2 		0.120 Biomarker disease BEFREE An international meta-analysis confirms the association of BNC2 with adolescent idiopathic scoliosis. 29549362 2018