Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE Hyperactivity of the mechanistic target of rapamycin complex 1 (mTORC1) is implicated in a variety of diseases such as cancer and diabetes. 31659101 2020
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE Overall, this study demonstrated that mTOR hyperactivity contributes to communication deficits in adult mice. 31586563 2020
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE A novel biomimetic 3D hydrogel platform that enables quantitative analysis of cell invasion and viability at the individual cell level is developed using automated data acquisition methods with an invasive lung disease (lymphangioleiomyomatosis, LAM) characterized by hyperactive mammalian target of rapamycin complex 1 (mTORC1) signaling as a model. 30589121 2019
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 AlteredExpression phenotype BEFREE These data demonstrate that neuronal mTOR hyperactivity levels influence the severity of epilepsy and associated neuropathology in experimental TSC and FCD. 30700531 2019
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE Hyperactive mTOR is an essential pathological mechanism in autism spectrum disorder (ASD). 31828304 2019
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 GeneticVariation phenotype BEFREE Next-generation sequencing identified somatic inactivating mutations of TSC2 (3/5 tumors tested) or activating mutations of MTOR (2/5) as the primary molecular alterations, consistent with hyperactive mTOR complex 1 signaling which was further demonstrated by phospho-S6 and phospho-4E-BP1 immunostaining. 30303819 2019
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE Hyperactivity of the mTOR pathway is associated with numerous human diseases, including diabetes, cancer and epilepsy. 31722960 2019
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE Everolimus (EVR), as a rapamycin analog, is a selective inhibitor of the mammalian target of rapamycin (mTOR) kinase and its associated signaling pathway. mTOR is a serine/threonine protein kinase and its hyperactivity is involved in the pathophysiology of Alzheimer's disease (AD) and associated cognitive deficits. 30564080 2018
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE Rapamycin and its chemical derivatives are the only drugs that inhibit the hyperactivity of mTOR, but numerous side effects have been described due to its therapeutic use. 30326670 2018
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE Mammalian Target of Rapamycin 1 (mTORC1) inhibitors have been tested for the treatment of liver cancer based on hyperactive mTOR in this malignancy. 29729190 2018
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 AlteredExpression phenotype BEFREE In the present study, we examine how neuron subset-specific deletion of Pten (NS-Pten) in mice, which presents with hyperactive mammalian target of rapamycin (mTOR) activity, affects the hippocampal protein levels of key neuropathological hallmarks of AD. 29965873 2018
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 AlteredExpression phenotype BEFREE Although we currently know that the neoplasm may result from the hyperactivity of protein kinase B (PKB or Akt) or extracellular-regulated kinase (Erk), which upregulates mammalian target of rapamycin kinase (mTOR) and leads to translation of proteins responsible for cell cycle regulation, there are still many questions to be answered. 28803490 2018
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE Aberrant autophagic flux was related to hyperactive mammalian target of rapamycin (mTOR), a major suppressor of autophagy. 29570219 2018
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE To find new anti-cancer drug therapies, we wanted to exploit homeostatic vulnerabilities within Tuberous Sclerosis Complex 2 (TSC2)-deficient cells with mechanistic target of rapamycin complex 1 (mTORC1) hyperactivity. 30308940 2018
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE Excessive mechanistic target of rapamycin complex 1 (mTORC1)-mediated hyper-glycolytic metabolism is responsible for the instability of TRAF3IP3-deficient T reg cells. 30115741 2018
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE Here we identified a role of mammalian target of rapamycin complex 1 (mTORC1) in the development of neural tissue, showing that it accelerates progenitor cell cycle progression and neurogenesis in mTORC1-hyperactive tuberous sclerosis complex 1 (Tsc1)-deficient mouse retina. 29950673 2018
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE Moreover, we demonstrated that PRAS40 down-regulates mTOR hyperactivity under stress conditions and alleviates neurotoxic prion peptide-induced apoptosis. 28294542 2017
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE Therefore, we sought to determine: 1) if MEK1/2 inhibition is sufficient to reduce REDD1 protein expression and subsequently insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation via negative feedback of hyperactive mTOR in REDD1 wild-type (WT) mice and 2) if rapamycin-mediated mTOR inhibition is sufficient to improve IRS-1 tyrosine phosphorylation in REDD1 knockout (KO) mice. 27913296 2017
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE Because mechanistic target of rapamycin (mTOR) negatively regulates autophagy and is hyperactive in the brains of patients with AD, mTOR is an attractive therapeutic target for AD. 28632947 2017
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE Abnormal synaptic transmission through metabotropic glutamate receptor 5 may underlie in a part of ASD associated with hyperactive mTOR-mediated signaling. 27071790 2016
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth. 25578782 2015
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE GCLC inhibition increased cellular stress and reduced mTOR hyperactivity in TSC2-depleted neurons and SEGA-derived cells. 26220190 2015
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE Therefore, enhanced STAT3/NF-κB-BEX2-VEGF signaling pathway contributes to hyperactive mTOR-induced tumorigenesis. 26296882 2015
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE However, whether hyperactive mTOR plays a role in the cognitive deficits associated with AD remains elusive. 24899720 2014
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.200 Biomarker phenotype BEFREE We will thus discuss the function of mTOR hyperactivity on neuronal circuit formation and the potential consequences of being born heterozygous on neuronal function and the biochemistry of synaptic plasticity, the cellular substrate of learning and memory. 23485365 2013