Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 AlteredExpression phenotype BEFREE Furthermore, Sod1-Tg mice that are administered AM are found to accumulate AM-associated nicotinamide in the central nervous system, and systemic supplementation of nicotinamide improves motor symptoms and gene expression patterns in the spinal cord of Sod1-Tg mice. 31330533 2019
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker phenotype BEFREE In transgenic mice overexpressing disease-causing human SOD1<sup>G37R</sup> or SOD1<sup>G93A</sup> mutations, treatment with the α-miSOD1 antibody delayed the onset of motor symptoms, extended survival by up to 2 months, and reduced aggregation of misfolded SOD1 and motor neuron degeneration. 30518612 2018
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker phenotype BEFREE GCLM(-/-)/hSOD1<sup>WT</sup> mice developed overt motor symptoms (e.g. tremor, loss of extension reflex in hind-limbs, decreased grip strength and paralysis) characteristic of mice models over-expressing ALS-linked mutant hSOD1. 29307609 2018
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker phenotype BEFREE When administered to SOD1 transgenic mice, there was a significant delay in motor symptom onset and prolonged survival. 29113829 2018
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker phenotype BEFREE Thus, alterations in body weight are present in ALS patients already decades before clinical manifestation of ALS, while weight loss precedes motor symptoms of several years and is associated with poor prognosis. 28975435 2017
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker phenotype BEFREE Our results from the SOD1 model suggest that dendritic and dendritic spine changes foreshadow and underpin the neuromotor phenotypes present in ALS and may contribute to the varied cognitive, executive function and extra-motor symptoms commonly seen in ALS patients. 27488828 2016
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation phenotype BEFREE Early changes of neuromuscular transmission in the SOD1(G93A) mice model of ALS start long before motor symptoms onset. 24040091 2013
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation phenotype BEFREE In addition, we have recently reported elevated heart rate and blood pressure in transgenic (TG) mice carrying the SOD1 mutant form of the human SOD1 transgene (SOD1-G93A) even prior to the appearance of motor symptoms. 23607704 2013
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation phenotype BEFREE After identification of the clinical onset in each female G93A mutant SOD1 transgenic mouse, we intraperitoneally administered multiple doses of edaravone to the mice and observed their motor symptoms. 18718468 2008
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation phenotype BEFREE Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice. 16478527 2006
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker phenotype BEFREE The mice heterozygotic for the human mutated SOD1 (D and DF) showed distinct ALS-like motor symptoms, whereas the mice heterozygotic for the normal SOD1 (W and WF) mice did not. 15857664 2005
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation phenotype BEFREE Motor neurons of the spinal cord in transgenic mice with a FALS-linked mutant SOD1 also showed a marked increase of GRP78/BiP, an ER-resident chaperone, just before the onset of motor symptoms. 12659845 2003