Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | phenotype | BEFREE | Intranasal Administration of Extracellular Vesicles Derived from Human Teeth Stem Cells Improves Motor Symptoms and Normalizes Tyrosine Hydroxylase Expression in the Substantia Nigra and Striatum of the 6-Hydroxydopamine-Treated Rats. | 30706999 | 2019 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | We observed no motor symptoms or changes in striatal [<sup>11</sup> C]DTBZ binding potential in vivo or striatal or SN TH staining in vitro between the groups. | 30009467 | 2018 | ||||
|
0.070 | AlteredExpression | phenotype | BEFREE | Immunohistochemical analysis of tyrosine hydroxylase (TH) showed that EA treatment had no effect on TH expression in the ipsilateral striatum or substantia nigra pars compacta, though it alleviated several of the parkinsonian motor symptoms. | 29508251 | 2018 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | PD rats were subjected to DBS of the STN (STN-DBS) and the effects on motor symptoms and number of nigral tyrosine hydroxylase-positive (TH<sup>+</sup>) neurons was examined. | 29792848 | 2018 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | Furthermore, these results suggest that short-term voluntary exercise is sufficient to alleviate cognition deficits and depressive behavior in 6-OHDA lesioned rats and long-term treatment reduces the progression of motor symptoms and elevates tyrosine hydroxylase (TH), Brain-derived neurotrophic factor (BDNF), bone marrow tyrosine kinase in chromosome X (BMX) protein expression level without affecting dopaminergic (DA) neuron loss in this PD rat model. | 29419747 | 2018 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | When we transplanted these cells into the unilateral lesioned SN induced by striatal injection of 6-hydroxydopamine (6-OHDA), a significant hypertrophy of nigral tyrosine hydroxylase (TH)(+) cells, an increase of striatal TH-staining and stabilization of amphetamine-induced motor symptoms were observed. | 20542127 | 2010 | ||||
|
0.070 | AlteredExpression | phenotype | BEFREE | The predominant loss of TH expression in striosomes occurred during the early postnatal period, when motor symptoms first appeared. | 18713855 | 2008 |