Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10021
Gene Symbol: HCN4
HCN4 		0.020 GeneticVariation phenotype LHGDN Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel. 16407510 2006
Entrez Id: 10021
Gene Symbol: HCN4
HCN4 		0.020 GeneticVariation phenotype LHGDN Pacemaker channel dysfunction in a patient with sinus node disease. 12750403 2003
Entrez Id: 287
Gene Symbol: ANK2
ANK2 		0.010 GeneticVariation phenotype LHGDN Targeted mutational analysis of ankyrin-B in 541 consecutive, unrelated patients referred for long QT syndrome genetic testing and 200 healthy subjects. 16253912 2005
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A 		0.010 GeneticVariation phenotype LHGDN SCN5A-linked Brugada patients were associated with a higher incidence of bradyarrhythmia (4 of 4) than non-SCN5A-linked Brugada patients (2 of 34). 16325048 2005
Entrez Id: 6863
Gene Symbol: TAC1
TAC1 		0.500 Biomarker phenotype CTD_human Facilitation by substance P and inhibition by (+)-tubocurarine of the 5-HT3 receptor-mediated Bezold-Jarisch reflex in rats. 8960879 1996
Entrez Id: 6863
Gene Symbol: TAC1
TAC1 		0.500 Biomarker phenotype RGD Microinjection of SP (1 ng) or NKA (10-100 ng) into the NTS caused prompt, transient hypotension and bradycardia, suggesting that SP and NKA may be neurotransmitters of the baroreceptor reflex in the NTS. 2471579 1989
Entrez Id: 6863
Gene Symbol: TAC1
TAC1 		0.500 Biomarker phenotype CTD_human The most sensitive sites where application of SP into the NTS evoked dose-dependent hypotension and bradycardia were at the level of the posterior tip of the area postrema (zero level) and at the level of the obex. 2445440 1987
Entrez Id: 776
Gene Symbol: CACNA1D
CACNA1D 		0.400 Biomarker phenotype HPO
Entrez Id: 776
Gene Symbol: CACNA1D
CACNA1D 		0.400 Biomarker phenotype CTD_human G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block. 26831068 2016
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.300 Biomarker phenotype CTD_human Hypotensive and bradycardic effects elicited by spinal dopamine receptor stimulation: effects of D1 and D2 receptor agonists and antagonists. 1724532 1991
Entrez Id: 11188
Gene Symbol: NISCH
NISCH 		0.300 Biomarker phenotype CTD_human Evidence for the involvement of central I1 imidazoline receptor in ethanol counteraction of clonidine hypotension in spontaneously hypertensive rats. 11486246 2001
Entrez Id: 1129
Gene Symbol: CHRM2
CHRM2 		0.300 Biomarker phenotype CTD_human Low-affinity M(2) receptor binding state mediates mouse atrial bradycardia: comparative effects of carbamylcholine and the M(1) receptor agonists sabcomeline and xanomeline. 11181912 2001
Entrez Id: 2771
Gene Symbol: GNAI2
GNAI2 		0.300 Biomarker phenotype CTD_human Endogenous RGS proteins modulate SA and AV nodal functions in isolated heart: implications for sick sinus syndrome and AV block. 17277016 2007
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6 		0.300 Biomarker phenotype CTD_human Cytochrome oxidase 2D6 gene polymorphism in primary open-angle glaucoma with various effects to ophthalmic timolol. 19284319 2009
Entrez Id: 1813
Gene Symbol: DRD2
DRD2 		0.300 Biomarker phenotype CTD_human Cardiovascular responses to intrathecal dopamine receptor agonists in conscious DOCA-salt hypertensive rats. 10626749 1999
Entrez Id: 5173
Gene Symbol: PDYN
PDYN 		0.300 Biomarker phenotype CTD_human Effects of dynorphin A(1-13) and of fragments of beta-endorphin on blood pressure and heart rate of anesthetized rats. 1676337 1991
Entrez Id: 5173
Gene Symbol: PDYN
PDYN 		0.300 Biomarker phenotype CTD_human Differential cardiovascular effects of mu, delta and kappa opiate agonists at discrete hypothalamic sites in the anesthetized rat. 6131355 1983
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A 		0.300 Biomarker phenotype CTD_human Evidence that central 5-HT1A-receptors play a role in the von Bezold-Jarisch reflex in the rat. 2207497 1990
Entrez Id: 5173
Gene Symbol: PDYN
PDYN 		0.300 Biomarker phenotype CTD_human Both dynorphin (1-13) and Leu-enkephalin administered s.c. to normal and morphine-tolerant rats, 30 min before blood vessel cannulation and testing, lowered the morphine ED50 for bradycardia. 6716269 1984
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.300 Biomarker phenotype CTD_human A small transient bradycardia was observed after i.c.v. administration of 10 micrograms of beta-endorphin(1-26), alpha, and gamma-endorphin. 1676337 1991
Entrez Id: 3827
Gene Symbol: KNG1
KNG1 		0.300 Biomarker phenotype CTD_human Mechanism of pain induced by radiocontrast media. 1281941 1992
Entrez Id: 5617
Gene Symbol: PRL
PRL 		0.300 Biomarker phenotype CTD_human In contrast, intraventricular administration of prolactin caused bradycardia, hypotension and an enhancement in the epinephrine-induced reflex bradycardia in conscious rats. 6350720 1983
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.300 Biomarker phenotype CTD_human Marked bradycardia during sleep was observed after the 16th day of ACTH therapy. 19039989 2008
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.300 Biomarker phenotype CTD_human It is concluded that a beta-endorphin-containing pathway projecting from the arcuate nucleus to the ipsilateral dorsal vagal complex is involved in depressor cardiovascular regulation and in the facilitation of baroreflex bradycardia. 2636709 1989
Entrez Id: 134
Gene Symbol: ADORA1
ADORA1 		0.300 Biomarker phenotype CTD_human Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: involvement of adenosine receptors. 18313046 2008