×
Entrez Id:
54551
Gene Symbol:
MAGEL2
MAGEL2
0.100
CausalMutation
phenotype
CLINVAR
×
Entrez Id:
54870
Gene Symbol:
QRICH1
QRICH1
0.100
CausalMutation
phenotype
CLINVAR
×
Entrez Id:
6863
Gene Symbol:
TAC1
TAC1
0.500
Biomarker
phenotype
CTD_human
Facilitation by substance P and inhibition by (+)-tubocurarine of the 5-HT3 receptor-mediated Bezold-Jarisch reflex in rats.
8960879
1996
×
Entrez Id:
6863
Gene Symbol:
TAC1
TAC1
0.500
Biomarker
phenotype
CTD_human
The most sensitive sites where application of SP into the NTS evoked dose-dependent hypotension and bradycardia were at the level of the posterior tip of the area postrema (zero level) and at the level of the obex.
2445440
1987
×
Entrez Id:
776
Gene Symbol:
CACNA1D
CACNA1D
0.400
Biomarker
phenotype
CTD_human
G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.
26831068
2016
×
Entrez Id:
1813
Gene Symbol:
DRD2
DRD2
0.300
Biomarker
phenotype
CTD_human
Hypotensive and bradycardic effects elicited by spinal dopamine receptor stimulation: effects of D1 and D2 receptor agonists and antagonists.
1724532
1991
×
Entrez Id:
1906
Gene Symbol:
EDN1
EDN1
0.300
Therapeutic
phenotype
CTD_human
Evidence for antagonistic activity of endothelin for clonidine induced hypotension and bradycardia.
1309933
1992
×
Entrez Id:
11188
Gene Symbol:
NISCH
NISCH
0.300
Biomarker
phenotype
CTD_human
Evidence for the involvement of central I1 imidazoline receptor in ethanol counteraction of clonidine hypotension in spontaneously hypertensive rats.
11486246
2001
×
Entrez Id:
2641
Gene Symbol:
GCG
GCG
0.300
Therapeutic
phenotype
CTD_human
Glucagon antagonized verapamil-induced hypotension and bradycardia in rats; however, glucagon's ability to antagonize other CCBs is unexplored.
3277781
1988
×
Entrez Id:
1129
Gene Symbol:
CHRM2
CHRM2
0.300
Biomarker
phenotype
CTD_human
Low-affinity M(2) receptor binding state mediates mouse atrial bradycardia: comparative effects of carbamylcholine and the M(1) receptor agonists sabcomeline and xanomeline.
11181912
2001
×
Entrez Id:
2771
Gene Symbol:
GNAI2
GNAI2
0.300
Biomarker
phenotype
CTD_human
Endogenous RGS proteins modulate SA and AV nodal functions in isolated heart: implications for sick sinus syndrome and AV block.
17277016
2007
×
Entrez Id:
3972
Gene Symbol:
LHB
LHB
0.300
Therapeutic
phenotype
CTD_human
Effects of anterior pituitary hormones and their releasing hormones on physiological and behavioral functions in rats.
6350720
1983
×
Entrez Id:
7200
Gene Symbol:
TRH
TRH
0.300
Therapeutic
phenotype
CTD_human
In addition, intraventricular administration of TRH , LHRH or LH caused tachycardia, hypertension and a reduction in the epinephrine-induced reflex bradycardia .
6350720
1983
×
Entrez Id:
1907
Gene Symbol:
EDN2
EDN2
0.300
Therapeutic
phenotype
CTD_human
Evidence for antagonistic activity of endothelin for clonidine induced hypotension and bradycardia.
1309933
1992
×
Entrez Id:
2641
Gene Symbol:
GCG
GCG
0.300
Therapeutic
phenotype
CTD_human
Glucagon , on the other hand, antagonized the acebutolol-induced bradycardia by 47% but exerted only a small activity on the hypotension.
6542785
1984
×
Entrez Id:
1565
Gene Symbol:
CYP2D6
CYP2D6
0.300
Biomarker
phenotype
CTD_human
Cytochrome oxidase 2D6 gene polymorphism in primary open-angle glaucoma with various effects to ophthalmic timolol.
19284319
2009
×
Entrez Id:
1813
Gene Symbol:
DRD2
DRD2
0.300
Biomarker
phenotype
CTD_human
Cardiovascular responses to intrathecal dopamine receptor agonists in conscious DOCA-salt hypertensive rats.
10626749
1999
×
Entrez Id:
2641
Gene Symbol:
GCG
GCG
0.300
Therapeutic
phenotype
CTD_human
Glucagon is considered the drug of choice for treating bradycardia and hypotension encountered during beta-blocker poisoning.
7787496
1995
×
Entrez Id:
4922
Gene Symbol:
NTS
NTS
0.300
Therapeutic
phenotype
CTD_human
Tonic suppression of baroreceptor reflex by endogenous neurotensin in the rat.
2326505
1990
×
Entrez Id:
5173
Gene Symbol:
PDYN
PDYN
0.300
Biomarker
phenotype
CTD_human
Effects of dynorphin A(1-13) and of fragments of beta-endorphin on blood pressure and heart rate of anesthetized rats.
1676337
1991
×
Entrez Id:
5173
Gene Symbol:
PDYN
PDYN
0.300
Biomarker
phenotype
CTD_human
Differential cardiovascular effects of mu, delta and kappa opiate agonists at discrete hypothalamic sites in the anesthetized rat.
6131355
1983
×
Entrez Id:
2641
Gene Symbol:
GCG
GCG
0.300
Therapeutic
phenotype
CTD_human
Glucagon administered either intravenously (iv) (100-1000 micrograms/kg) or intracerebroventricularly (icv) (5 micrograms) significantly attenuated morphine-induced (200 micrograms/kg, iv) bradycardia without producing any alterations in cardiovascular parameters when given alone.
3736332
1986
×
Entrez Id:
1906
Gene Symbol:
EDN1
EDN1
0.300
Therapeutic
phenotype
CTD_human
ET-1 significantly (P < 0.0005) potentiated the hypertensive response of a low dose (50 micrograms/kg i.v.) of clonidine in cervical-sectioned rats.I.c.v. administration of clonidine (1, 2, 4 and 6 micrograms) produced a dose-dependent decrease in blood pressure and heart rate.ET-1 pretreatment (25 ng i.c.v.) transiently blocked the clonidine-induced decrease in blood pressure and heart rate for about 10 min but the hypotension and bradycardia was observed subsequently.
8440307
1993
×
Entrez Id:
2641
Gene Symbol:
GCG
GCG
0.300
Therapeutic
phenotype
CTD_human
A potential role for glucagon in the treatment of drug-induced symptomatic bradycardia.
9674488
1998
×
Entrez Id:
3350
Gene Symbol:
HTR1A
HTR1A
0.300
Biomarker
phenotype
CTD_human
Evidence that central 5-HT1A-receptors play a role in the von Bezold-Jarisch reflex in the rat.
2207497
1990