| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.380 | Biomarker | disease | BEFREE | <b>Context:</b> Insulin-like peptide 3 (INSL3), a protein hormone produced by Leydig cells, may play a crucial role in testicular descent as male INSL3 knockout mice have bilateral cryptorchidism. | 31611843 | 2019 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | In conclusion, the evidence suggests that mutations of INSL3 may not directly contribute to the damage of spermatogenesis in patients with bilateral cryptorchidism history. | 26840636 | 2016 | ||||
|
0.380 | Biomarker | disease | BEFREE | Definitive evidence of its role in rodent testis descent is illustrated by the phenotype of bilateral cryptorchidism in Insl3-/- null mice. | 18647820 | 2008 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | The common INSL3 G178A polymorphism was not statistically significantly associated with male infertility (P>.05), even though INSL3 is essential for the occurrence of bilateral cryptorchidism. | 17559848 | 2007 | ||||
|
0.380 | Biomarker | disease | CTD_human | Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. | 16102138 | 2006 | ||||
|
0.380 | Biomarker | disease | CTD_human | Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis. | 14687758 | 2004 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | Two independent studies demonstrated that transgenic mice with a targeted deletion of the insulin-like 3 ( INSL3) gene presented bilateral cryptorchidism. | 12601553 | 2003 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | Knockout male mice for the INSL3 gene show isolated bilateral cryptorchidism. | 11992081 | 2002 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | The phenotype of transgenic mice with targeted deletion of the Insl3 gene was bilateral cryptorchidism with morphological evidence of abnormal gubernacular development. | 11095425 | 2000 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | We sequenced both exons of the human INSL3 gene in 31 men who presented with idiopathic unilateral or bilateral cryptorchidism. | 10729310 | 2000 |