Gene: DNM1 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 GeneticVariation disease CLINVAR A class of dynamin-like GTPases involved in the generation of the tubular ER network. 19665976 2009
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 GeneticVariation disease CLINVAR Large-scale discovery of novel genetic causes of developmental disorders. 25533962 2015
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 GeneticVariation disease CLINVAR Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. 12509422 2003
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 GeneticVariation disease CLINVAR Dynamin 2 homozygous mutation in humans with a lethal congenital syndrome. 23092955 2013
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 GeneticVariation disease CLINVAR Proper synaptic vesicle formation and neuronal network activity critically rely on syndapin I. 21926968 2011
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 GeneticVariation disease CLINVAR Multiple forms of dynamin are encoded by shibire, a Drosophila gene involved in endocytosis. 1828536 1991
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 GeneticVariation disease CLINVAR Predominant and developmentally regulated expression of dynamin in neurons. 1832879 1991
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 GeneticVariation disease CLINVAR A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. 17463283 2007
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 GeneticVariation disease CLINVAR Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission. 22099461 2011
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 GeneticVariation disease CLINVAR Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding. 7877694 1995
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 GeneticVariation disease CLINVAR Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic. 1674590 1991
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 GeneticVariation disease CLINVAR DNM1 encephalopathy: A new disease of vesicle fission. 28667181 2017
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 GeneticVariation disease CLINVAR Dynamin GTPase domain mutants block endocytic vesicle formation at morphologically distinct stages. 11553700 2001
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 CausalMutation disease CLINVAR Cell- and stimulus-dependent heterogeneity of synaptic vesicle endocytic recycling mechanisms revealed by studies of dynamin 1-null neurons. 18250322 2008
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 CausalMutation disease CLINVAR SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic function. 21441247 2011
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 CausalMutation disease CLINVAR Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. 12509422 2003
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 CausalMutation disease CLINVAR The crystal structure of dynamin. 21927001 2011
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 CausalMutation disease CLINVAR A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice. 20700442 2010
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 CausalMutation disease CLINVAR Homotypic fusion of ER membranes requires the dynamin-like GTPase atlastin. 19633650 2009
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 CausalMutation disease CLINVAR A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. 17463283 2007
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 CausalMutation disease CLINVAR A lethal defect of mitochondrial and peroxisomal fission. 17460227 2007
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 CausalMutation disease CLINVAR Multiple forms of dynamin are encoded by shibire, a Drosophila gene involved in endocytosis. 1828536 1991
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 CausalMutation disease CLINVAR Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice. 11879655 2002
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 CausalMutation disease CLINVAR Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease. 15731758 2005
Entrez Id: 1759
Gene Symbol: DNM1
DNM1 		0.100 CausalMutation disease CLINVAR Dynamin GTPase domain mutants block endocytic vesicle formation at morphologically distinct stages. 11553700 2001