Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5657
Gene Symbol: PRTN3
PRTN3 		0.010 Biomarker group BEFREE Proteinase 3-antineutrophil cytoplasmic antibody-positive ulcerative colitis presenting with abducens neuropathy. 28069788 2017
Entrez Id: 8989
Gene Symbol: TRPA1
TRPA1 		0.040 Biomarker group BEFREE TRPA1 is a Ca<sup>2+</sup>-permeable ion channel involved in many sensory disorders such as pain, itch and neuropathy. 28332600 2017
Entrez Id: 7170
Gene Symbol: TPM3
TPM3 		0.010 Biomarker group BEFREE Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by <i>Gars</i> mutations. 28351971 2017
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1 		0.010 Biomarker group BEFREE Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by <i>Gars</i> mutations. 28351971 2017
Entrez Id: 5376
Gene Symbol: PMP22
PMP22 		0.100 Biomarker group BEFREE PMP22Δ4 is another example of a mutated myelin protein that is misfolded and contributes to the pathogenesis of the neuropathy. 28382305 2017
Entrez Id: 2764
Gene Symbol: GMFB
GMFB 		0.010 Biomarker group BEFREE GMF-β may therefore be a good biomarker for disease risk assessment and to estimate host neuropathy after exposure to T. gondii, as well as providing a new therapeutic target. 28774213 2017
Entrez Id: 343641
Gene Symbol: TGM6
TGM6 		0.020 Biomarker group BEFREE Transglutaminase 6 antibodies in gluten neuropathy. 28886934 2017
Entrez Id: 8989
Gene Symbol: TRPA1
TRPA1 		0.040 Biomarker group BEFREE TRPA1 channel mediates organophosphate-induced delayed neuropathy. 28894590 2017
Entrez Id: 2232
Gene Symbol: FDXR
FDXR 		0.010 GeneticVariation group BEFREE FDXR Mutations Cause Sensorial Neuropathies and Expand the Spectrum of Mitochondrial Fe-S-Synthesis Diseases. 28965846 2017
Entrez Id: 23114
Gene Symbol: NFASC
NFASC 		0.050 Biomarker group BEFREE Neurofascin-155 IGG4 Neuropathy: Pathophysiological Insights, Spectrum of Clinical Severity and Response To treatment. 29130507 2018
Entrez Id: 23114
Gene Symbol: NFASC
NFASC 		0.050 Biomarker group BEFREE Neurofascin antibodies were 4 times more frequent in autoimmune neuropathy samples compared to genetic neuropathy controls. 29187518 2018
Entrez Id: 4322
Gene Symbol: MMP13
MMP13 		0.020 Biomarker group BEFREE MMP-13 inhibition also reversed neuropathy in diabetic mice. 29306589 2018
Entrez Id: 11343
Gene Symbol: MGLL
MGLL 		0.010 Biomarker group BEFREE Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy. 29540562 2018
Entrez Id: 213
Gene Symbol: ALB
ALB 		0.030 Biomarker group BEFREE Serum albumin (P = .002), paclitaxel dose (P = .001), and body surface area (P = .006) were statistically significantly associated with a positive rTNS change (worsening neuropathy). 29696771 2018
Entrez Id: 1266
Gene Symbol: CNN3
CNN3 		0.010 Biomarker group BEFREE Calponin 3 is a novel autoantigen.Antibodies against this protein are found in SS and associate with the subset of patients experiencing neuropathies. 29749720 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.100 Biomarker group BEFREE Tumor necrosis factor-α (TNFα) is a cytokine that mainly mediates neurogenic inflammation through the ligand receptor TNF receptor 1 (TNFR1), and targeting TNFα/TNFR1 signaling is a direction toward treating inflammatory diseases and injury-induced neuropathy. 30173779 2018
Entrez Id: 55244
Gene Symbol: SLC47A1
SLC47A1 		0.010 AlteredExpression group BEFREE Mate1 siRNA-injected rats developed more severe neuropathy than control rats. 30295925 2019
Entrez Id: 11009
Gene Symbol: IL24
IL24 		0.020 Biomarker group BEFREE MDA7 represents an innovative therapeutic approach for treatment of chemotherapy-induced neuropathy. 30414958 2019
Entrez Id: 407042
Gene Symbol: MIR34C
MIR34C 		0.010 Biomarker group BEFREE MiR-34c Participates in Diabetic Corneal Neuropathy Via Regulation of Autophagy. 30601927 2019
Entrez Id: 100128998
Gene Symbol: C20orf181
C20orf181 		0.010 Biomarker group BEFREE Tissue plasminogen activator and neuropathy open the blood-nerve barrier with upregulation of microRNA-155-5p in male rats. 30625382 2019
Entrez Id: 1463
Gene Symbol: NCAN
NCAN 		0.010 Biomarker group BEFREE Neurocan is a New Substrate for the ADAMTS12 Metalloprotease: Potential Implications in Neuropathies. 30977985 2019
Entrez Id: 10558
Gene Symbol: SPTLC1
SPTLC1 		0.060 Biomarker group BEFREE Hereditary sensory neuropathy type 1 (HSN1) is a rare, slowly progressive neuropathy causing profound sensory deficits and often severe motor loss. 30995999 2019
Entrez Id: 23098
Gene Symbol: SARM1
SARM1 		0.040 Biomarker group BEFREE SARM1 (sterile alpha and TIR motif containing 1) is responsible for depletion of nicotinamide adenine dinucleotide in its oxidized form (NAD<sup>+</sup>) during Wallerian degeneration associated with neuropathies. 31439792 2019
Entrez Id: 343641
Gene Symbol: TGM6
TGM6 		0.020 Biomarker group BEFREE Transglutaminase 6 antibodies (anti-TG6) have been considered a biomarker for gluten-related ataxia and neuropathy, but their prevalence in epilepsies with cerebral calcifications is unknown. 31698178 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1 		0.010 Biomarker group BEFREE IFN was effective in controlling purpura (80%) but was moderately effective on severe haematuria/proteinuria, renal insufficiency and neuropathy. 9431896 1997