Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE Our results demonstrated a high variability of individual endometrial cancer samples in the levels of PTEN. 29477866 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE Durable partial response was observed in a patient with endometrial cancer harboring PIK3R1 and PTEN truncating mutations, and 13 additional patients (28%) had a decrease in their target lesions by up to 30%.<b>Conclusions:</b> LY3023414 has a tolerable safety profile and single-agent activity in patients with advanced cancers. 29636360 2018
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
0.800 GeneticVariation disease BEFREE Mutations in MSH6 were less prevalent, and MSH6 mutation carriers presented with colorectal and endometrial cancer at later ages than carriers of mutations in MSH2 or MLH1. 28772289 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Proliferation, transwell and apoptosis assay suggested that MDH2 enhanced the proliferation, migration and invasion but inhibited the apoptosis of endometrial cancer cell line through suppressing PTEN. 28189066 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE miR-200a and miR-200b can promote the endometrial cancer cell growth in vitro by targeted inhibition of PTEN gene expression. 28647188 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE TTF-1 and PTEN can be used as molecular markers for the early diagnosis of endometrial cancer, which are closely related to clinical features and may affect tumor progression by regulating the proliferation activity of tumor cells. 28745797 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE Moreover, miR-205 was found to negatively regulate PTEN expression and lead to autophagy and activation of the AKT/mTOR pathway in PR cells, and PTEN protein levels significantly decreased with development of progesterone resistance in endometrial cancer cells. 28427207 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Furthermore, treatment with mTOR inhibitors reduced colony size and proliferation of a PTEN negative endometrial cancer cell line in 3D culture. 27980219 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE Analysis of the TCGA RNA-Seq mRNA expression of ER, PR, PIK3CA, PTEN and SFN (gene for 14-3-3σ) confirmed increased PR expression in EC of obese women. 28476021 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE The frequency of PTEN alterations is particularly high in endometrial carcinomas. 28349562 2017
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
0.800 GeneticVariation disease BEFREE To our knowledge, this is the first case of endometrial carcinoma of the LUS with MSH6 germline mutation. 27928858 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE The PI3K/PTEN/AKT pathway is the most frequently mutated pathway in endometrial carcinoma. 27910071 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE In our study, the nuclear and cytoplasmic study of immunoxpression p53, both in hyperplastic lesions and in the endometroid endometrial carcinoma, was negative, similar to the immunohistochemical expression of PTEN. 29250656 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE The levels of HE4 were determined by ELISA, the levels of cancer antigen CA125 and CA15.3 by chemiluminescent immunoassay, and the levels of mRNA expression of survivin, β-catenin, miR-15a, and PTEN by RT-PCR assay from endometrial carcinoma samples. 28039713 2017
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
0.800 Biomarker disease BEFREE Here we describe our institution's experience with a prospective universal screening protocol in which all ECs resected over a period of 19 months (n=242) were screened for MLH1, PMS2, MSH2, and MSH6 deficiencies using IHC, followed by MLH1 promoter methylation testing when appropriate. 27556954 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Using endometrial cancer cellular models with known PTEN status, we evaluated their homologous recombination (HR) functionality by RAD51 foci formation assay. 28886696 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE PTEN expression was statistically significant in the overall survival (OS) rate of women with endometrial cancers (p=0.041). 28220037 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE To test the hypothesis that insulin signalling plays a key role in the development of EC in women with PCOS by measuring and comparing the expression of three key genes involved in the insulin signalling pathway (IGF1, PTEN and IGFBP1) in endometrial tissue obtained from three groups of women; PCOS without EC, women with EC without PCOS and non-PCOS women without EC (controls). 26802879 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE We hypothesized that in PTEN-mutated endometrial cancers, hyperactive Akt signaling downregulates progesterone receptor B (PRB) transcriptional activity, leading to overall impaired progestin responses. 26996671 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE This study aims to investigate the new role of lncRNA FER1L4 in EC pathogenesis due to its correlation with phosphatase and tensin homolog (PTEN), one important indicator of EC progression. 27381864 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE CCNE1 amplification was independent of p53, HER2, MLH1 and ARID1A expression but dependent on PTEN expression in endometrial carcinomas. 26647729 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE We identified a high frequency of mutations in PTEN (50%) and genes involved in the endometrial cancer-related molecular pathway, which involves the IL-7 signaling pathway (PIK3R1, n=1; AKT2, n=1; FOXO1, n=1). 26626801 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE In xenografts models of PTEN-positive and PTEN-knock-in endometrial cancer, JQ1 significantly upregulated the expression of PTEN, blocked the PI3K/AKT signaling pathway and suppressed tumor growth. 27572308 2016
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
0.800 PosttranslationalModification disease BEFREE We analyzed immunohistochemistry of MMR proteins (MLH1/MSH2/MSH6/PMS2) and MLH1 promoter methylation in primary endometrial carcinomas from 221 consecutive patients. 26644264 2016
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
0.800 AlteredExpression disease BEFREE Multivariate survival analysis revealed that MSH6 gene expression was associated with outcome of endometrial cancer patients independently from traditional prognostic clinicopathologic parameters, which was confirmed in an independent cohort at the protein level. 27420608 2016