Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 AlteredExpression disease BEFREE Immunhistochemistry profiling of human endometrial cancer tissue biopsies identified epithelial cells co-expressing ERβ5 and ERα in stage I endometrial adenocarcinomas and post menopausal endometrium. 31778358 2020
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Estrogen receptor (ER), progesterone receptor (PR), and Ki-67 and P53 receptor levels in endometrial curettage material were investigated for their ability to predict lymph node (LN) involvement in patients with endometrioid-type endometrial cancer (EEC). 31395281 2020
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Notably, InsR-β inhibition had a limited effect on estradiol-dependent proliferation, cell cycle, and apoptosis, whereas ER-α inhibition had a limited insulin-dependent effect, in EC cell lines. 31119046 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Conditioned medium from selective ERα agonist-treated M2 macrophages induced the epithelial to mesenchymal transition (EMT) in endometrial cancer cells. 30779215 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE To assess the effect of skincare product use on the risk of pre- and postmenopausal breast cancer, estrogen receptor positive (ER+) and negative (ER-) breast cancer and cancer of the endometrium. 31796030 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Endocrine therapy by blocking the estrogen and estrogen receptor α (ERα) has been effective in breast cancer, while it is still controversial in EC. 31686835 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Compared to that of the general population, the incidence of EC following estrogen receptor-positive (ER+) breast cancer and hormone receptor-negative (HR-) breast cancer increased by approximately 16-fold and 15-fold, respectively. 31576449 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE miR‑107‑5p promotes tumor proliferation and invasion by targeting estrogen receptor‑α in endometrial carcinoma. 30569100 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 AlteredExpression disease BEFREE Proline-, glutamic acid-, and leucine-rich protein-1 (PELP1), a co-regulatory molecule of estrogen receptor α (ER α), is up-regulated in series of cancers such as endometrial carcinoma, ovarian cancer, colorectal cancer, breast cancer, and non-small cell lung cancer. 31322541 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE The aim of this retrospective study was to explore the possible correlation in the EC microenvironment between master regulators of complex phenomena such as steroid responsiveness through estrogen receptor alpha (ERα) and progesterone receptor (PR), epithelial-to-mesenchymal transition (supported by SLUG transcription factor), hypoxia (with hypoxia inducible factor-1 alpha, HIF-1α), and obesity that has been recognized as a EC risk factor. 31220580 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 GeneticVariation disease BEFREE Using a unique CRISPR/Cas9 strategy, we introduced the D538G mutation, a common endometrial cancer mutation that alters the ligand binding domain of ESR1, while epitope tagging the endogenous locus. 31362937 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 AlteredExpression disease BEFREE Immunohistochemistry revealed an overexpression of phospho-NPM/B23 (Thr199) in human endometrial cancer, and phospho-NPM/B23 (Thr199) expression levels were inversely associated with Erα in clinical specimen. 31330844 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Despite a high proportion of endometrioid ECs being ER and/or PR positive, endocrine therapy is only effective in a minority of women with EC and ultimately patients progress with resistance developing to treatment. 30616900 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 AlteredExpression disease BEFREE A20 increased functional ERα protein levels and enhanced estrogen-driven EC cell proliferation through preventing ERα protein degradation by its deubiquitinase activity. 30420335 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE This easy, simple, and highly efficient criterion should be recommended for routine assessment of ER in EC patients. 29406446 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 AlteredExpression disease BEFREE HEC-1A and KLE, ERα-negative endometrial cancer cells exhibiting high ERRα expression levels, and HEC-1A cell-derived xenograft model mice were treated with XCT790. 30706380 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Therefore, in view of modularization, this study is to conduct an in-depth analysis on the effects of estrogen receptor alpha (ERα) regarding EC. 31140648 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Targeted Next-Generation Sequencing Identifies Actionable Targets in Estrogen Receptor Positive and Estrogen Receptor Negative Endometriod Endometrial Cancer. 30057548 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 AlteredExpression disease BEFREE We herein investigate AR expression across ECA subtypes and compare its expression to estrogen receptor (ER) and progesterone receptor (PR). 28582344 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Overall, Efp would exert a tumor-promoting role through modulating NF-κB pathway and 14-3-3σ protein degradation in endometrial cancer regardless of its estrogen receptor status. 30586414 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Taken together, our study first showed that Hsd could be an antiestrogenic compound that could modulate nongenomic estrogen receptor signaling through inhibition of EC cell growth. 29665555 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE A total of 43 high-grade endometrial carcinoma cases initially classified as pure high-grade endometrioid carcinoma (n=32), mixed high-grade endometrioid carcinoma/serous carcinoma (n=9) and mixed high-grade endometrioid carcinoma/clear cell carcinoma (n=2) were retrospectively stained with a panel of immunostains, including antibodies for p53, p16, estrogen receptor, and mammaglobin. 28984301 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 AlteredExpression disease BEFREE Thus, our goal was to assess the effect of the isoflavones, novasoy and genistein, on cell proliferation, cell cycle, apoptosis, progesterone receptor (PR) and estrogen receptor-alpha (ERα) expression and the AKT/mTOR and MAPK pathways in endometrial cancer cells. 29636868 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 AlteredExpression disease BEFREE The mRNA and protein expression levels of ERRα and estrogen receptor α (ERα) were detected by qPCR and Western blotting in RL-952, AN3-CA, HEC-1A, and HEC-1B EC cell lines. 30127640 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.600 Biomarker disease BEFREE Clinical and Genomic Crosstalk between Glucocorticoid Receptor and Estrogen Receptor α In Endometrial Cancer. 29539426 2018